Terpestacin
Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 146436-22-8
- Formula: C25H38O4
- Molecular Weight:402.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 146436-22-8
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Molecular Weight 402.57
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Formula C25H38O4
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SMILES
OC[C@@H](C)C1=C(C([C@@]2([C@@]1(C/C=C([C@H](CC/C(C)=C/CC/C(C)=C/C2)O)\C)[H])C)=O)O
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Structure Classification
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Initial Source
Phoma exigua var. heteromorpha
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Masi M, et al. Terpestacin, a toxin produced by Phoma exigua var. heteromorpha, the causal agent of a severe foliar disease of oleander (Nerium oleander L.). Nat Prod Res. 2022 Mar;36(5):1253-1259. [Content Brief]
[2]. Jung HJ, et al. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem. 2010 Apr 9;285(15):11584-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Terpestacin Related Classifications
HY-N15497 Related Classifications
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