146436-22-8
146436-22-8
Chemical Structure
Terpestacin
- CAS No.: 146436-22-8
- Formula:C25H38O4
- Molecular Weight:402.57
SMILES: OC[C@@H](C)C1=C(C([C@@]2([C@@]1(C/C=C([C@H](CC/C(C)=C/CC/C(C)=C/C2)O)\C)[H])C)=O)O
Biological Activity: Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity[1][2].
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Terpestacin | Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity. | |||||||||||||||||||||
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References
- [1]. Masi M, et al. Terpestacin, a toxin produced by Phoma exigua var. heteromorpha, the causal agent of a severe foliar disease of oleander (Nerium oleander L.). Nat Prod Res. 2022 Mar;36(5):1253-1259. [Content Brief]
- [2]. Jung HJ, et al. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem. 2010 Apr 9;285(15):11584-95. [Content Brief]
Keywords
