ACAP1 - ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Gene

Also Known as CENTB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9744

About ACAP1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,336,529-7,351,477 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 187 orthologues and 28 paralogues. Broad expression in lymph node (RPKM 20.4), spleen (RPKM 16.9) and 24 other tissues.

Summary

Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in protein transport and regulation of catalytic activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ACAP1 Products (1)

mRNA Protein Name
NM_014716.4 NP_055531.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAP1 Protein Structure

PH

PH: PH domain (267 - 359)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (407 - 521)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (592 - 670)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

  • Arf GAP with coiled coil, ANK repeat and PH domains 1

ACAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACAP1 Q15027 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
Intra
ACAP1 Q15027 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
Intra
ACAP1 Q15027 NEBL Homo sapiens O76041
Y2H Array
32296183
Intra
ACAP1 Q15027 NEBL Homo sapiens O76041
Y2H Prey Pooling
32296183
Intra
ACAP1 Q15027 GRB2 Homo sapiens P62993
Peptide Array
17474147
Intra
ACAP1 Q15027 UQCRB Homo sapiens P14927
Y2H Prey Pooling
32296183
Intra
ACAP1 Q15027 UQCRB Homo sapiens P14927
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myoclonic Epilepsy, Juvenile 3

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 3

  • EJM3

  • Epilepsy, Juvenile Myoclonic 3

  • Juvenile Myoclonic Epilepsy 3
Benign Ileal Neoplasm

  • Ileal Tumor

  • Ileal Neoplasms

  • Ileal Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00133 ACAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20848 Acap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27362 Acap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACAP1 MGD MGI:2388270
Canis familiaris ACAP1 VGNC VGNC:37496
Rattus norvegicus ACAP1 RGD RGD:1305360
Bos taurus ACAP1 VGNC VGNC:25526
Felis catus ACAP1 VGNC VGNC:59497
Macaca mulatta ACAP1 VGNC VGNC:69427
Others ACAP1 NCBI