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Cat. No.: HY-187021

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3-Carboxyumbelliferyl acetate

3-Carboxyumbelliferyl acetate (compound ACC) is a fluorescent substrate that can be used to detect the activity of the Escherichia coli polysaccharide deacetylase PgaB, with a K_m of 1.2 mM and a k_cat of 0.013 s⁻¹. 3-Carboxyumbelliferyl acetate undergoes acetate hydrolysis under the catalysis of E. coli PgaB. 3-Carboxyumbelliferyl acetate can be used in studies related to PgaB enzymatic activity and the mechanism of bacterial biofilm formation.

For research use only. We do not sell to patients.

CAS No.: 81017-23-4
Formula: C₁₂H₈O₆
Molecular Weight:248.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-Carboxyumbelliferyl acetate Chemical Structure

CAS No.: 81017-23-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PgaB

1.2 mM (Km)

In Vitro

3-Carboxyumbelliferyl acetate (compound ACC) (up to 10 mM) serves as a soluble and stable substrate for purified E. coli PgaB, and is applicable for assaying the catalytic activity of PgaB, with a K_m value of 1.2 mM and a kcat value of 0.013 s⁻¹^[1].
3-Carboxyumbelliferyl acetate serves as a competitive substrate in assays evaluating inhibitors of E. coli PgaB, which can confirm the competitive binding of active inhibitors to the PgaB active site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81017-23-4
Molecular Weight 248.19
Formula C₁₂H₈O₆
SMILES

O=C(O)C1=CC=2C=CC(OC(=O)C)=CC2OC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chibba A, et al. Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation. Organic & Biomolecular Chemistry. 2012;10:7103-7107.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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