country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-137846A

Copy Link Print Information

PF-05221304 tromethamine

PF-05221304 tromethamine is an orally active, liver-directed and dual ACC1/ACC2 inhibitor with IC₅₀s of 7.5 nM for rat ACC1, 8.2 nM for rat ACC2. PF-05221304 tromethamine is a substrate for organic anion transport polypeptides. PF-05221304 tromethamine directly improves a variety of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) pathogenic factors.

For research use only. We do not sell to patients.

CAS No.: 2334472-62-5
Formula: C₃₂H₄₁N₅O₈
Molecular Weight:623.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PF-05221304 tromethamine Chemical Structure

CAS No.: 2334472-62-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 7.5 nM for rat ACC1, 8.2 nM for rat ACC2^[1]

In Vitro

PF-05221304 tromethamine inhibits hepatic de novo lipogenesis (DNL) with an IC₅₀ of 61 nM in human hepatocytes (donor HH AA 508) in a concentration-dependent manner. PF-05221304 tromethamine stimulates fatty acid oxidation and reduces triglyceride accumulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-05221304 (5 mg/kg; p.o.; twice a day; 6 weeks) tromethamine reduces the expression of these genes (a-SMA, Col1A1, Col3A1, CCL2 and CCL11), which increases by pre-treatment with choline-deficient and high-fat diet (CDAHFD). It shows chronic administration of PF-05221304 tromethamine decreases hepatic inflammation and fibrosis in choline-deficient and high-fat diet-fed rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar Han rats^[1]
Dosage:

5 mg/kg
Administration:

Oral administration; twice a day; 6 weeks
Result:

Reduced the expression of these genes (a-SMA, Col1A1, Col3A1, CCL2 and CCL11) by 46% (P <0.01), 40% (P < 0.01), 44% (P < 0.05), 61% (P < .001) and 45% (P < .05), respectively.

Chemical Information

CAS No. 2334472-62-5
Molecular Weight 623.71
Formula C₃₂H₄₁N₅O₈
SMILES

O=C(O)C=1C=CC(=CC1)C2=NC(OC)=CC(=C2)C(=O)N3CCC4(CC(=O)C5=C(C=NN5C(C)C)C4)CC3.OCC(N)(CO)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Trenton T Ross, et al. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems. Cell Mol Gastroenterol Hepatol. 2020;10(4):829-851. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote