Procyanidin C2
Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated AMPKα and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 37064-31-6
- 分子式: C45H38O18
- 分子量:866.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
体外実験
Procyanidin C2 (10 μM) reduces lipid accumulation, TG levels, and TC levels in Oleic acid (HY-N1446)-induced HepG2 cells[1].
Procyanidin C2 (10 μM) improves redox balance in oleic acid-induced HepG2 cells by increasing SOD activity, decreasing MDA levels, and reducing intracellular and mitochondrial-derived ROS[1].
Procyanidin C2 (10 μM) improves mitochondrial function in oleic acid-induced HepG2 cells by increasing mitochondrial membrane potential and mass, and restoring mitochondrial ultrastructure[1].
Procyanidin C2 (10 μM) regulates lipid metabolism in oleic acid-induced HepG2 cells by reducing lipogenic protein expression, increasing fatty acid oxidation-related protein expression, enhancing oxidative stress response proteins, and modulating the AMPK/mTOR signaling pathway via increased p-AMPKα, increased p-JNK, and decreased p-mTOR[1].
Procyanidin C2 (fractions derived from 200 μg/mL GSPE stock; 5 min) displays obvious antioxidant activity in a cell-free ABTS radical cation scavenging assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 37064-31-6
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分子量 866.77
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分子式 C45H38O18
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SMILES
OC1=C([C@@H](C2=C(O[C@H](C3=CC(O)=C(O)C=C3)[C@@H](O)C4)C4=C(O)C=C2O)[C@H](O)[C@@H](C5=CC(O)=C(O)C=C5)O6)C6=C([C@@H]([C@@H]([C@@H](C7=CC(O)=C(O)C=C7)O8)O)C(C8=CC(O)=C9)=C9O)C(O)=C1
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別名
Procyanidine C2
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tie F, et al. B-Type Trimeric Procyanidins Attenuate Nonalcoholic Hepatic Steatosis Through AMPK/mTOR Signaling Pathway in Oleic Acid-Induced HepG2 Cells and High-Fat Diet- Fed Zebrafish. Plant Foods Hum Nutr. 2025;80(1):44. Published 2025 Jan 23. [Content Brief]
[2]. Gao J, et al. Bioactivity-based antioxidative components screening and evaluation in grape seed proanthocyanidin extract. J Food Sci Technol. 2017;54(9):2645-2652. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Procyanidin C2 関連分類
HY-N7521 関連分類
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