Procyanidin C2
Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated AMPKα and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease.
For research use only. We do not sell to patients.
- CAS No.: 37064-31-6
- Formula: C45H38O18
- Molecular Weight:866.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Procyanidin C2 (10 μM) reduces lipid accumulation, TG levels, and TC levels in Oleic acid (HY-N1446)-induced HepG2 cells[1].
Procyanidin C2 (10 μM) improves redox balance in oleic acid-induced HepG2 cells by increasing SOD activity, decreasing MDA levels, and reducing intracellular and mitochondrial-derived ROS[1].
Procyanidin C2 (10 μM) improves mitochondrial function in oleic acid-induced HepG2 cells by increasing mitochondrial membrane potential and mass, and restoring mitochondrial ultrastructure[1].
Procyanidin C2 (10 μM) regulates lipid metabolism in oleic acid-induced HepG2 cells by reducing lipogenic protein expression, increasing fatty acid oxidation-related protein expression, enhancing oxidative stress response proteins, and modulating the AMPK/mTOR signaling pathway via increased p-AMPKα, increased p-JNK, and decreased p-mTOR[1].
Procyanidin C2 (fractions derived from 200 μg/mL GSPE stock; 5 min) displays obvious antioxidant activity in a cell-free ABTS radical cation scavenging assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 37064-31-6
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Molecular Weight 866.77
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Formula C45H38O18
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SMILES
OC1=C([C@@H](C2=C(O[C@H](C3=CC(O)=C(O)C=C3)[C@@H](O)C4)C4=C(O)C=C2O)[C@H](O)[C@@H](C5=CC(O)=C(O)C=C5)O6)C6=C([C@@H]([C@@H]([C@@H](C7=CC(O)=C(O)C=C7)O8)O)C(C8=CC(O)=C9)=C9O)C(O)=C1
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Synonyms
Procyanidine C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tie F, et al. B-Type Trimeric Procyanidins Attenuate Nonalcoholic Hepatic Steatosis Through AMPK/mTOR Signaling Pathway in Oleic Acid-Induced HepG2 Cells and High-Fat Diet- Fed Zebrafish. Plant Foods Hum Nutr. 2025;80(1):44. Published 2025 Jan 23. [Content Brief]
[2]. Gao J, et al. Bioactivity-based antioxidative components screening and evaluation in grape seed proanthocyanidin extract. J Food Sci Technol. 2017;54(9):2645-2652. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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