Procyanidin C2  (Synonyms: Procyanidine C2)

Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated AMPKα and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease^[1].

Procyanidin C2 (10 μM) reduces lipid accumulation, TG levels, and TC levels in Oleic acid (HY-N1446)-induced HepG2 cells^[1].
Procyanidin C2 (10 μM) improves redox balance in oleic acid-induced HepG2 cells by increasing SOD activity, decreasing MDA levels, and reducing intracellular and mitochondrial-derived ROS^[1].
Procyanidin C2 (10 μM) improves mitochondrial function in oleic acid-induced HepG2 cells by increasing mitochondrial membrane potential and mass, and restoring mitochondrial ultrastructure^[1].
Procyanidin C2 (10 μM) regulates lipid metabolism in oleic acid-induced HepG2 cells by reducing lipogenic protein expression, increasing fatty acid oxidation-related protein expression, enhancing oxidative stress response proteins, and modulating the AMPK/mTOR signaling pathway via increased p-AMPKα, increased p-JNK, and decreased p-mTOR^[1].
Procyanidin C2 (fractions derived from 200 μg/mL GSPE stock; 5 min) displays obvious antioxidant activity in a cell-free ABTS radical cation scavenging assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procyanidin C2 significantly reduces lipid accumulation, oxidative stress, and lipogenic gene expression while increasing antioxidant levels and lipid metabolism-regulating gene expression in high-fat diet-induced NAFLD zebrafish^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

866.77

C₄₅H₃₈O₁₈

37064-31-6

OC1=C([C@@H](C2=C(O[C@H](C3=CC(O)=C(O)C=C3)[C@@H](O)C4)C4=C(O)C=C2O)[C@H](O)[C@@H](C5=CC(O)=C(O)C=C5)O6)C6=C([C@@H]([C@@H]([C@@H](C7=CC(O)=C(O)C=C7)O8)O)C(C8=CC(O)=C9)=C9O)C(O)=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tie F, et al. B-Type Trimeric Procyanidins Attenuate Nonalcoholic Hepatic Steatosis Through AMPK/mTOR Signaling Pathway in Oleic Acid-Induced HepG2 Cells and High-Fat Diet- Fed Zebrafish. Plant Foods Hum Nutr. 2025;80(1):44. Published 2025 Jan 23.

  [2]. Gao J, et al. Bioactivity-based antioxidative components screening and evaluation in grape seed proanthocyanidin extract. J Food Sci Technol. 2017;54(9):2645-2652.