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Cat. No.: HY-169009

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(Rac)-Spirotetramat-enol

(Rac)-Spirotetramat-enol is a ligand of acetyl-CoA carboxylase (ACC) that can be used for the synthesis of PROTAC ACC degrader-1 (HY-169008). (Rac)-Spirotetramat-enol binds to the carboxyltransferase domain and inhibits ACC activity in insects and spider mites. (Rac)-Spirotetramat-enol exhibits insecticidal activity against nymphs of the black bean aphid. (Rac)-Spirotetramat-enol can be used in studies related to black bean aphid infestation.

For research use only. We do not sell to patients.

CAS No.: 382608-09-5
Formula: C₁₈H₂₃NO₃
Molecular Weight:301.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

(Rac)-Spirotetramat-enol Chemical Structure

CAS No.: 382608-09-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

(Rac)-Spirotetramat-enol (0.39-50 μM; 48 h) does not significantly downregulate ACC protein levels in Sf9 cells^[1].
(Rac)-Spirotetramat-enol (25 μM; 8 h) pretreatment of Sf9 cells significantly inhibits the ACC-degrading activity of compound 9b^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Sf9 cells
Concentration:

0.39 μM; 1.56 μM; 6.25 μM; 25 μM; 50 μM
Incubation Time:

48 h
Result:

Caused only nonsignificant downregulation of ACC protein levels across all tested concentrations.
Showed no concentration-dependent degradation of ACC protein.

Western Blot Analysis^[1]

Cell Line:

Sf9 cells
Concentration:

25 μM (pretreatment)
Incubation Time:

8 h (pretreatment)
Result:

Significantly reduced the ACC-degrading activity of compound 9b in Sf9 cells.

Chemical Information

CAS No. 382608-09-5
Molecular Weight 301.38
Formula C₁₈H₂₃NO₃
SMILES

O=C1NC2(CCC(CC2)OC)C(O)=C1C3=C(C)C=CC(C)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Q, et al. Acetyl-CoA Carboxylase Proteolysis-Targeting Chimeras: Conceptual Design and Application as Insecticides. Journal of agricultural and food chemistry. 2024 Aug 28;72(34):18809-18815. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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