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DRG1 - developmentally regulated GTP binding protein 1 Gene

Also Known as NEDD3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4733

About DRG1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,399,604-31,434,452 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 4 paralogues. Broad expression in testis (RPKM 112.9), thyroid (RPKM 23.8) and 24 other tissues.

Summary

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

DRG1 Products (1)

mRNA	Protein	Name
NM_004147.4	NP_004138.1	developmentally-regulated GTP-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	23711155	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23711155	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	28855639	GOA
enables potassium ion binding	IDA IDA: Inferred from direct assay	23711155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	28855639	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	28855639	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19819225	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29915238	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRG1 Protein Structure

MMR_HSR1

TGS

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
developmentally-regulated GTP-binding protein 1	DRG-1

DRG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Anti Tag CoIP	28514442
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Y2H Array	25416956
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Y2H Array	32296183
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Y2H Prey Pooling	25416956
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Anti Tag CoIP	35271311
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Y2H Prey Pooling	32296183
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Y2H	21516116
Intra	DRG1	Q9Y295	ZC3H15	Homo sapiens	Q8WU90	Anti Tag CoIP	33961781
Intra	DRG1	Q9Y295	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	DRG1	Q9Y295	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	DRG1	Q9Y295	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	DRG1	Q9Y295	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	DRG1	Q9Y295	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	DRG1	Q9Y295	SKIL	Homo sapiens	P12757	Y2H Array	25416956
Intra	DRG1	Q9Y295	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	DRG1	Q9Y295	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Y2H Prey Pooling	32296183
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Y2H Array	25416956
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Y2H Array	32296183
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Y2H Pooling	16189514
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Pull Down	16189514
Intra	DRG1	Q9Y295	RWDD1	Homo sapiens	Q9H446	Y2H Prey Pooling	25416956
Intra	DRG1	Q9Y295	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	DRG1	Q9Y295	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	DRG1	Q9Y295	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
Intra	DRG1	Q9Y295	COIL	Homo sapiens	P38432	Validated Y2H	25416956
Intra	DRG1	Q9Y295	COIL	Homo sapiens	P38432	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5	CMTX5 Rosenberg-Chutorian Syndrome Charcot-Marie-Tooth Disease X-Linked Recessive 5 Optic Atrophy, Polyneuropathy, And Deafness Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5 Cmt5x X-Linked Charcot-Marie-Tooth Disease Type 5 Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5 Optic Atrophy Polyneuropathy Deafness Optic Atrophy With Polyneuropathy And Deafness Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17382	Ndrg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04009	DRG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09114	NDRG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15720	VTA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18925	Drg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25415	Drg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DRG1	VGNC	VGNC:84729
Felis catus	DRG1	VGNC	VGNC:61630
Canis familiaris	DRG1	VGNC	VGNC:40097
Rattus norvegicus	DRG1	RGD	RGD:1304993
Bos taurus	DRG1	VGNC	VGNC:53899
Mus musculus	DRG1	MGD	MGI:1343297
Others	DRG1	NCBI