SKIL - SKI like proto-oncogene Gene

Homo sapiens

Also known as SNO; SnoA; SnoI; SnoN

Gene ID: 6498 | Gene type: protein coding

About SKIL

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,357,715-170,396,849 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 14.0), appendix (RPKM 11.3) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SKIL Products(4)

mRNA	Protein	Name
NM_001145097.2	NP_001138569.1	ski-like protein isoform 2
NM_001145098.3	NP_001138570.1	ski-like protein isoform 3
NM_001248008.1	NP_001234937.1	ski-like protein isoform 1
NM_005414.5	NP_005405.2	ski-like protein isoform 1

SKIL Protein Structure

Ski_Sno

c-SKI_SMAD_bind

0
200
400
600
684 a.a.

Protein Preferred Names

Protein Names

ski-like protein

SKI-like oncogene

Related Diseases

Diseases

Alias

Obstructive Nephropathy

Con	Congenital Obstructive Nephropathy
Nephropathy Obstructive

Cornea Cancer

Malignant Neoplasm Of Cornea	Neoplasm Of Cornea
Corneal Tumor	Malignant Corneal Tumor
Malignant Tumor Of Cornea	Primary Malignant Neoplasm Of Cornea

Renal Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12970	SKIL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SKIL	VGNC	VGNC:65171
Macaca mulatta	SKIL	VGNC	VGNC:84081
Canis familiaris	SKIL	VGNC	VGNC:46199
Mus musculus	SKIL	MGD	MGI:106203
Rattus norvegicus	SKIL	RGD	RGD:621399
Bos taurus	SKIL	VGNC	VGNC:34648