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SKIL - SKI like proto-oncogene Gene

Also Known as SNO; SnoA; SnoI; SnoN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6498

About SKIL

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,357,715-170,396,849 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 14.0), appendix (RPKM 11.3) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SKIL Products (4)

mRNA	Protein	Name
NM_001145097.2	NP_001138569.1	ski-like protein isoform 2
NM_001145098.3	NP_001138570.1	ski-like protein isoform 3
NM_001248008.1	NP_001234937.1	ski-like protein isoform 1
NM_005414.5	NP_005405.2	ski-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10531062	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10531062	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	12764135	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8514802	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8514802	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18334480	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18334480	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10531062	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	17469184	GOA
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	16675394	GOA
involved in response to antibiotic	IEP IEP: Inferred from expression pattern	15967445	GOA
involved in response to growth factor	IDA IDA: Inferred from direct assay	19383336	GOA
involved in skeletal muscle tissue development	IDA IDA: Inferred from direct assay	17202138	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	19383336	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16109768	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14712482	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23610558	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKIL Protein Structure

Ski_Sno

c-SKI_SMAD_bind

0
200
400
600
684 a.a.

Protein Preferred Names	Protein Names
ski-like protein	SKI-like oncogene

SKIL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SKIL	P12757	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
Intra	SKIL	P12757	SMAD2	Homo sapiens	Q15796	Y2H	15231748
Intra	SKIL	P12757	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SKIL	P12757	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SKIL	P12757	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SKIL	P12757	XPA	Homo sapiens	P23025	Validated Y2H	32296183
Intra	SKIL	P12757	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	SKIL	P12757	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	SKIL	P12757	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	SKIL	P12757	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	SKIL	P12757	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	SKIL	P12757	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	SKIL	P12757	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SKIL	P12757	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SKIL	P12757	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SKIL	P12757	OIP5	Homo sapiens	O43482	Y2H Array	25416956
Intra	SKIL	P12757	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	SKIL	P12757	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	SKIL	P12757	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	SKIL	P12757	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	SKIL	P12757	DRG1	Homo sapiens	Q9Y295	Y2H Prey Pooling	25416956
Intra	SKIL	P12757	DRG1	Homo sapiens	Q9Y295	Validated Y2H	25416956
Intra	SKIL	P12757	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SKIL	P12757	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SKIL	P12757	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SKIL	P12757	VPS28	Homo sapiens	Q9UK41	Y2H	21516116
Intra	SKIL	P12757	DEUP1	Homo sapiens	Q05D60	Validated Y2H	32296183
Intra	SKIL	P12757	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	SKIL	P12757	NXF3	Homo sapiens	Q9H4D5	Y2H Array	25416956
Intra	SKIL	P12757	ATP1A3	Homo sapiens	P13637	Y2H Pooling	32814053
Intra	SKIL	P12757	ATP1A3	Homo sapiens	P13637	Validated Y2H	32814053
Intra	SKIL	P12757	ATP1A3	Homo sapiens	P13637	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Obstructive Nephropathy	Con Congenital Obstructive Nephropathy Nephropathy Obstructive
Cornea Cancer	Malignant Neoplasm Of Cornea Neoplasm Of Cornea Corneal Tumor Malignant Corneal Tumor Malignant Tumor Of Cornea Primary Malignant Neoplasm Of Cornea
Renal Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12970	SKIL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SKIL	VGNC	VGNC:65171
Macaca mulatta	SKIL	VGNC	VGNC:84081
Canis familiaris	SKIL	VGNC	VGNC:46199
Mus musculus	SKIL	MGD	MGI:106203
Rattus norvegicus	SKIL	RGD	RGD:621399
Bos taurus	SKIL	VGNC	VGNC:34648
Others	SKIL	NCBI