XPA - XPA, DNA damage recognition and repair factor Gene

Also Known as XP1; XPAC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7507

About XPA

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,654,398-97,697,340 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and is associated with 43 phenotypes. Ubiquitous expression in thyroid (RPKM 6.2), fat (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes a Zinc Finger Protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin Cancer. [provided by RefSeq, Aug 2017]

XPA Products (2)

mRNA	Protein	Name
NM_000380.4	NP_000371.1	DNA repair protein complementing XP-A cells isoform 1
NM_001354975.2	NP_001341904.1	DNA repair protein complementing XP-A cells isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	7700386	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7700386	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17720715	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8197175	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IDA IDA: Inferred from direct assay	1601884	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	1601884	GOA
involved in UV protection	IDA IDA: Inferred from direct assay	1601884	GOA
involved in UV protection	IMP IMP: Inferred from mutant phenotype	1601884	GOA
involved in nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	21148310	GOA
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	1601884	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DNA replication factor A complex	IDA IDA: Inferred from direct assay	7700386	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1601884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPA Protein Structure

XPA_N

XPA_C

0
100
200
273 a.a.

Protein Preferred Names	Protein Names
DNA repair protein complementing XP-A cells	xeroderma pigmentosum group A-complementing protein

XPA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XPA	P23025	HERC2	Homo sapiens	O95714	Anti Bait CoIP	20304803
Intra	XPA	P23025	HERC2	Homo sapiens	O95714	Anti Tag CoIP	20304803
Intra	XPA	P23025	HERC2	Homo sapiens	O95714	Anti Tag CoIP	33961781
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992-3	Y2H Prey Pooling	32296183
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992-3	Y2H Array	32296183
Intra	XPA	P23025	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	XPA	P23025	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	XPA	P23025	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	XPA	P23025	SIRT1	Homo sapiens	Q96EB6	Deacetylase Assay	20670893
Intra	XPA	P23025	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	20670893
Intra	XPA	P23025	SKIL	Homo sapiens	P12757	Y2H Array	32296183
Intra	XPA	P23025	SKIL	Homo sapiens	P12757	Y2H Prey Pooling	32296183
Intra	XPA	P23025	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	XPA	P23025	SNPH	Homo sapiens	O15079	Y2H Prey Pooling	32296183
Intra	XPA	P23025	SNPH	Homo sapiens	O15079	Y2H Array	32296183
Intra	XPA	P23025	ARID3A	Homo sapiens	Q99856	Validated Y2H	32296183
Intra	XPA	P23025	ARID3A	Homo sapiens	Q99856	Y2H Prey Pooling	32296183
Intra	XPA	P23025	ARID3A	Homo sapiens	Q99856	Y2H Array	32296183
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Anti Bait CoIP	20670893
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Anti Tag CoIP	33961781
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Y2H Prey Pooling	32296183
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Anti Tag CoIP	20304803
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Y2H Array	32296183
Intra	XPA	P23025	RPA2	Homo sapiens	P15927	Anti Bait CoIP	12527904
Intra	XPA	P23025	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	XPA	P23025	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	XPA	P23025	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	XPA	P23025	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	XPA	P23025	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	XPA	P23025	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	XPA	P23025	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	XPA	P23025	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	Cosedimentation	17948053
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	Pull Down	16491090
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	Anti Tag CoIP	28514442
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	Anti Tag CoIP	33961781
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	NMR	17948053
Intra	XPA	P23025	ERCC1	Homo sapiens	P07992	GMS	17948053
Intra	XPA	P23025	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	XPA	P23025	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	XPA	P23025	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	XPA	P23025	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	32296183
Intra	XPA	P23025	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183
Intra	XPA	P23025	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

XPA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810939	XPA Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89858	XPA Antibody (YA9202)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Complementation Group A	Xeroderma Pigmentosum Group A Xp1 Xeroderma Pigmentosum, Group A XPA Xeroderma Pigmentosum I Xeroderma Pigmentosum Complementation Group A Xp Group A Xp, Group A Xeroderma Pigmentosum 1 Xeroderma Pigmentosum, Type 1 XP-A
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Xeroderma Pigmentosum, Complementation Group F	Xeroderma Pigmentosum, Group F Xeroderma Pigmentosum Vi Xp6 Xeroderma Pigmentosum, Type F/Cockayne Syndrome XPF Xp, Group F Xeroderma Pigmentosum Group F Xp Group F Xeroderma Pigmentosum, Type 6 Xeroderma Pigmentosum Complementation Group F XP-F Xeroderma Pigmentosum Type F/Cockayne Syndrome XPF/CS
Multiple Self-Healing Squamous Epithelioma	MSSE Ess1 Ferguson-Smith Type Epithelioma Ferguson-Smith Disease Self-Healing Squamous Epithelioma Type 1 Multiple Self-Healing Squamous Epithelioma, Susceptibility To Ferguson-Smith-Type Epithelioma Ess1, Formerly Multiple Self Healing Squamous Epithelioma Familial Primary Self-Healing Squamous Epithelioma Of The Skin, Ferguson-Smith Type Multiple Keratoacanthoma, Ferguson-Smith Type Epithelioma, Squamous, Multiple Self Healing
Xeroderma Pigmentosum, Complementation Group C	Xeroderma Pigmentosum, Group C XPC Xpcc Xeroderma Pigmentosum Iii Xp3 Xeroderma Pigmentosum Group C Xp Group C Xp, Group C Xeroderma Pigmentosum, Type 3 Xeroderma Pigmentosum Complementation Group C XP-C
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Xfe Progeroid Syndrome	Xpf-Ercc1 Progeroid Syndrome XFEPS
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
De Sanctis-Cacchione Syndrome	Xerodermic Idiocy Xeroderma Pigmentosum With Neurologic Manifestation DSC Xerodermic Idiocy Of De Sanctis And Cacchione
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
Brain Sarcoma	Sarcoma Of The Brain
Cerebrooculofacioskeletal Syndrome	Cerebro-Oculo-Facio-Skeletal Syndrome Cofs Syndrome Pena-Shokeir Syndrome Type 2 Pena Shokeir Syndrome Type 2
Xeroderma Pigmentosum Group E	Xeroderma Pigmentosum, Group E Xeroderma Pigmentosum V Xp Group E Xp5 Xpe Xeroderma Pigmentosum, Complementation Group E
Xeroderma Pigmentosum, Complementation Group B	Xeroderma Pigmentosum Group B Xeroderma Pigmentosum, Group B XPB Xpbc Xp Group B Xp, Group B Xeroderma Pigmentosum Complementation Group B XP-B Xeroderma Pigmentosum Group B With Cockayne Syndrome Xeroderma Pigmentosum Ii Xp2 Xp-B/Cs
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1
Xeroderma Pigmentosum, Complementation Group E	Xeroderma Pigmentosum V Xp5 Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype Xpe Xp, Group E Xeroderma Pigmentosum, Type 5 Xeroderma Pigmentosum Complementation Group E XP-E Xp Group E
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Photoparoxysmal Response 1	Photosensitivity Disease Photodermatitis Photosensitivity Disorders PPR1 Ppr Photosensitivity Photoconvulsive Reaction Epilepsy, Photogenic Photosensitivity Of Skin Dermatitis, Phototoxic
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139038	TDRL-X80		99.6%	Unkown
HY-161623	ERCC1/XPA interaction inhibitor 1	Inhibitor	/	Unkown
HY-RS15884	XPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22088	Xpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28608	Xpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XPA	MGD	MGI:99135
Canis familiaris	XPA	VGNC	VGNC:48455
Macaca mulatta	XPA	VGNC	VGNC:78808
Bos taurus	XPA	VGNC	VGNC:36992
Rattus norvegicus	XPA	RGD	RGD:1308769
Felis catus	XPA	VGNC	VGNC:103008
Others	XPA	NCBI