NDEL1 - nudE neurodevelopment protein 1 like 1 Gene
Also Known as EOPA; NDE2; NUDEL; MITAP1; NDE1L1
Species: Homo sapiens
About NDEL1
This gene has 19 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), adrenal (RPKM 13.4) and 25 other tissues.
Summary
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
NDEL1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001025579.3 | NP_001020750.1 | nuclear distribution protein nudE-like 1 isoform A |
| NM_001330129.2 | NP_001317058.1 | nuclear distribution protein nudE-like 1 isoform C |
| NM_030808.5 | NP_110435.1 | nuclear distribution protein nudE-like 1 isoform B |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
10931877 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10931877 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in chromosome segregation |
IMP
IMP: Inferred from mutant phenotype
|
17600710 | GOA |
| involved in positive regulation of GTPase activity |
IMP
IMP: Inferred from mutant phenotype
|
21283621 | GOA |
| involved in regulation of intracellular protein transport |
IMP
IMP: Inferred from mutant phenotype
|
21283621 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in kinetochore |
IDA
IDA: Inferred from direct assay
|
17600710 | GOA |
NDEL1 Protein Structure
NUDE_C: NUDE protein, C-terminal conserved region (135 - 336)
- 0
- 100
- 200
- 300
- 345 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nuclear distribution protein nudE-like 1 |
|
NDEL1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
NDEL1 | Q9GZM8 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF572 | Homo sapiens | Q7Z3I7 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF572 | Homo sapiens | Q7Z3I7 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | MBIP | Homo sapiens | Q9NS73-5 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | MBIP | Homo sapiens | Q9NS73-5 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | BORCS6 | Homo sapiens | Q96GS4 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | BORCS6 | Homo sapiens | Q96GS4 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF844 | Homo sapiens | Q08AG5 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF844 | Homo sapiens | Q08AG5 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF260 | Homo sapiens | Q3ZCT1 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF662 | Homo sapiens | Q6ZS27-3 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF662 | Homo sapiens | Q6ZS27-3 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF180 | Homo sapiens | Q9UJW8 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF180 | Homo sapiens | Q9UJW8 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF180 | Homo sapiens | Q9UJW8 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | CEP135 | Homo sapiens | Q66GS9 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CEP135 | Homo sapiens | Q66GS9 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | MIS18A | Homo sapiens | Q9NYP9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MIS18A | Homo sapiens | Q9NYP9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MIS18A | Homo sapiens | Q9NYP9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MIS18A | Homo sapiens | Q9NYP9 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | DIXDC1 | Homo sapiens | Q155Q3 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | DIXDC1 | Homo sapiens | Q155Q3 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CCSER1 | Homo sapiens | Q9C0I3 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CCSER1 | Homo sapiens | Q9C0I3 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF490 | Homo sapiens | Q9ULM2 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF490 | Homo sapiens | Q9ULM2 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF490 | Homo sapiens | Q9ULM2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | IMMT | Homo sapiens | Q16891-1 | 20880836 | |
|
Intra
|
NDEL1 | Q9GZM8 | IMMT | Homo sapiens | Q16891-1 | 20880836 | |
|
Intra
|
NDEL1 | Q9GZM8 | PXN | Homo sapiens | P49023-2 | 19492042 | |
|
Intra
|
NDEL1 | Q9GZM8 | PXN | Homo sapiens | P49023-2 | 19492042 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | SNAPC5 | Homo sapiens | O75971-2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | SNAPC5 | Homo sapiens | O75971-2 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | CLVS2 | Homo sapiens | Q5SYC1 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | CLVS2 | Homo sapiens | Q5SYC1 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5-1 | 17043677 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5-1 | 20880836 | |
|
Intra
|
NDEL1 | Q9GZM8 | BMI1 | Homo sapiens | P35226 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | CHAT | Homo sapiens | P28329-3 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF264 | Homo sapiens | Q14C61 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF264 | Homo sapiens | Q14C61 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | BRK1 | Homo sapiens | Q8WUW1 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF544 | Homo sapiens | Q6NX49 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF544 | Homo sapiens | Q6NX49 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF544 | Homo sapiens | Q6NX49 | 31515488 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF445 | Homo sapiens | P59923 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF445 | Homo sapiens | P59923 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | XPA | Homo sapiens | P23025 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | XPA | Homo sapiens | P23025 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | PARVG | Homo sapiens | Q9HBI0 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MED11 | Homo sapiens | Q9P086 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MED11 | Homo sapiens | Q9P086 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MED11 | Homo sapiens | Q9P086 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5 | 12812986 | |
|
Intra
|
NDEL1 | Q9GZM8 | DISC1 | Homo sapiens | Q9NRI5 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CWF19L2 | Homo sapiens | Q2TBE0 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | CWF19L2 | Homo sapiens | Q2TBE0 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | PKP2 | Homo sapiens | Q99959 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | PKP2 | Homo sapiens | Q99959 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | CCSER2 | Homo sapiens | Q9H7U1 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CCSER2 | Homo sapiens | Q9H7U1 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDC80 | Homo sapiens | O14777 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDC80 | Homo sapiens | O14777 | 29892012 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRIM27 | Homo sapiens | P14373 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | PAFAH1B1 | Homo sapiens | P43034 | 10931877 | |
|
Intra
|
NDEL1 | Q9GZM8 | PAFAH1B1 | Homo sapiens | P43034 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | DTNB | Homo sapiens | O60941 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF417 | Homo sapiens | Q8TAU3 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | NUP54 | Homo sapiens | Q7Z3B4 | 31413325 | |
|
Intra
|
NDEL1 | Q9GZM8 | NUP54 | Homo sapiens | Q7Z3B4 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
NDEL1 | Q9GZM8 | ABI3 | Homo sapiens | Q9P2A4 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | USP2 | Homo sapiens | O75604 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | SNAPC5 | Homo sapiens | O75971 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRAF3IP3 | Homo sapiens | Q9Y228 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRAF3IP3 | Homo sapiens | Q9Y228 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | TRAF3IP3 | Homo sapiens | Q9Y228 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF57 | Homo sapiens | Q68EA5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF57 | Homo sapiens | Q68EA5 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF599 | Homo sapiens | Q96NL3 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | ZNF599 | Homo sapiens | Q96NL3 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 22843697 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 22843697 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 22843697 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 25416956 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 10931877 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 32296183 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 22843697 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDEL1 | Homo sapiens | Q9GZM8 | 17997972 | |
|
Intra
|
NDEL1 | Q9GZM8 | NDE1 | Homo sapiens | Q9NXR1 | 33961781 | |
|
Intra
|
NDEL1 | Q9GZM8 | CENPF | Homo sapiens | P49454 | 17600710 | |
|
Intra
|
NDEL1 | Q9GZM8 | CENPF | Homo sapiens | P49454 | 17600710 | |
|
Intra
|
NDEL1 | Q9GZM8 | CENPF | Homo sapiens | P49454 | 31413325 |
NDEL1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82227 | NDEL1 Antibody (YA1972) | WB, IHC-P | Human, Mouse, Rat |
| HY-P83349 | NDEL1 Antibody (YA3094) | WB | Human, Mouse |
| HY-P83349A | NDEL1 Antibody (YA3094)(PBS only) | WB | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lissencephaly |
|
|
| Miller-Dieker Lissencephaly Syndrome |
|
|
| Lissencephaly 4 |
|
|
| Lissencephaly 1 |
|
|
| Microlissencephaly |
|
|
| Chromosome 17p13.3, Centromeric, Duplication Syndrome |
|
|
| Neuronopathy, Distal Hereditary Motor, Type Viib |
|
|
| Band Heterotopia |
|
|
| Bipolar Disorder |
|
|
| Schizophrenia |
|
|
| Autism |
|
|
| Congenital Nervous System Abnormality |
|
|
| Psychotic Disorder |
|
|
| Periventricular Nodular Heterotopia |
|
|
| Primary Autosomal Recessive Microcephaly |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | NDEL1 | VGNC | VGNC:31933 |
| Rattus norvegicus | NDEL1 | RGD | RGD:621235 |
| Canis familiaris | NDEL1 | VGNC | VGNC:43672 |
| Mus musculus | NDEL1 | MGD | MGI:1932915 |
| Macaca mulatta | NDEL1 | VGNC | VGNC:74982 |
| Felis catus | NDEL1 | VGNC | VGNC:63749 |
| Others | NDEL1 | NCBI |