NDEL1 - nudE neurodevelopment protein 1 like 1 Gene

Also Known as EOPA; NDE2; NUDEL; MITAP1; NDE1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81565

About NDEL1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,413,131-8,474,328 (from NCBI)

This gene has 19 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), adrenal (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

NDEL1 Products (3)

mRNA Protein Name
NM_001025579.3 NP_001020750.1 nuclear distribution protein nudE-like 1 isoform A
NM_001330129.2 NP_001317058.1 nuclear distribution protein nudE-like 1 isoform C
NM_030808.5 NP_110435.1 nuclear distribution protein nudE-like 1 isoform B
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10931877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10931877 GOA
Biological Process GO Annotation Evidence References Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
17600710 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
21283621 GOA
involved in regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
21283621 GOA
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
17600710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDEL1 Protein Structure

NUDE_C

NUDE_C: NUDE protein, C-terminal conserved region (135 - 336)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

nuclear distribution protein nudE-like 1

  • endooligopeptidase A

NDEL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162 25416956
Intra
NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162 25416956
Intra
NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7 25416956
Intra
NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7 25416956
Intra
NDEL1 Q9GZM8 CCHCR1 Homo sapiens Q8TD31-3 25416956
Intra
NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5 25416956
Intra
NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5 25416956
Intra
NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4 32296183
Intra
NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4 32296183
Intra
NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5 25416956
Intra
NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5 25416956
Intra
NDEL1 Q9GZM8 ZNF260 Homo sapiens Q3ZCT1 25416956
Intra
NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3 32296183
Intra
NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3 32296183
Intra
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 25416956
Intra
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 31413325
Intra
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 25416956
Intra
NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9 33961781
Intra
NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9 31413325
Intra
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
Intra
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
Intra
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
Intra
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 31413325
Intra
NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3 31413325
Intra
NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3 33961781
Intra
NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3 33961781
Intra
NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3 31413325
Intra
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 25416956
Intra
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 25416956
Intra
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 32296183
Intra
NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1
Y2H
20880836
Intra
NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1 20880836
Intra
NDEL1 Q9GZM8 PXN Homo sapiens P49023-2 19492042
Intra
NDEL1 Q9GZM8 PXN Homo sapiens P49023-2 19492042
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2 32296183
Intra
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2 32296183
Intra
NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1 32296183
Intra
NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1 32296183
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1
Y2H
17043677
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1 20880836
Intra
NDEL1 Q9GZM8 BMI1 Homo sapiens P35226 25416956
Intra
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
Intra
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
Intra
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
Intra
NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61 25416956
Intra
NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61 25416956
Intra
NDEL1 Q9GZM8 BRK1 Homo sapiens Q8WUW1 31413325
Intra
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 25416956
Intra
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 31413325
Intra
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 31515488
Intra
NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923 31413325
Intra
NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923 33961781
Intra
NDEL1 Q9GZM8 XPA Homo sapiens P23025 25416956
Intra
NDEL1 Q9GZM8 XPA Homo sapiens P23025 25416956
Intra
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
Intra
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
Intra
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
Intra
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
Intra
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
Intra
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
Intra
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
Intra
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
Intra
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
Intra
NDEL1 Q9GZM8 PARVG Homo sapiens Q9HBI0 32296183
Intra
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
Intra
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
Intra
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
Intra
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5 33961781
Intra
NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0 25416956
Intra
NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0 25416956
Intra
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
Intra
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
Intra
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
Intra
NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959 25416956
Intra
NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959 25416956
Intra
NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1 33961781
Intra
NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1 31413325
Intra
NDEL1 Q9GZM8 NDC80 Homo sapiens O14777 25416956
Intra
NDEL1 Q9GZM8 NDC80 Homo sapiens O14777 29892012
Intra
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 32296183
Intra
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 33961781
Intra
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 32296183
Intra
NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034
Y2H
10931877
Intra
NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034 33961781
Intra
NDEL1 Q9GZM8 DTNB Homo sapiens O60941 25416956
Intra
NDEL1 Q9GZM8 ZNF417 Homo sapiens Q8TAU3 25416956
Intra
NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4 31413325
Intra
NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4 33961781
Intra
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
Intra
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
Intra
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
Intra
NDEL1 Q9GZM8 ABI3 Homo sapiens Q9P2A4 32296183
Intra
NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03 32296183
Intra
NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03 32296183
Intra
NDEL1 Q9GZM8 MTUS2 Homo sapiens Q5JR59 25416956
Intra
NDEL1 Q9GZM8 USP2 Homo sapiens O75604 25416956
Intra
NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155 25416956
Intra
NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155 25416956
Intra
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971 25416956
Intra
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 25416956
Intra
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 32296183
Intra
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 25416956
Intra
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
Intra
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
Intra
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
Intra
NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5 32296183
Intra
NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5 32296183
Intra
NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3 25416956
Intra
NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3 25416956
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
GMS
22843697
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 25416956
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H
10931877
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
Intra
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 17997972
Intra
NDEL1 Q9GZM8 NDE1 Homo sapiens Q9NXR1 33961781
Intra
NDEL1 Q9GZM8 CENPF Homo sapiens P49454 17600710
Intra
NDEL1 Q9GZM8 CENPF Homo sapiens P49454
Y2H
17600710
Intra
NDEL1 Q9GZM8 CENPF Homo sapiens P49454 31413325
Cross: Cross-species interaction Intra: Intraspecies interaction

NDEL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82227 NDEL1 Antibody (YA1972) WB, IHC-P Human, Mouse, Rat
HY-P83349 NDEL1 Antibody (YA3094) WB Human, Mouse
HY-P83349A NDEL1 Antibody (YA3094)(PBS only) WB Human, Mouse

Related Diseases

Diseases Alias
Lissencephaly
  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria

Miller-Dieker Lissencephaly Syndrome
  • Miller-Dieker Syndrome

  • Mds

  • MDLS

  • Miller Dieker Syndrome

  • Classical Lissencephaly Syndrome

  • Lissencephaly Due To 17p13.3 Deletion

  • Monosomy 17p13.3

  • Telomeric Deletion 17p

  • Classical Lissencephaly

Lissencephaly 4
  • LIS4

  • Lissencephaly 4 With Microcephaly

  • Microlissencephaly

  • Lissencephaly, Type 4

Lissencephaly 1
  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly

Microlissencephaly
Chromosome 17p13.3, Centromeric, Duplication Syndrome
  • Chromosome 17p13.3 Duplication Syndrome

  • 17p13.3 Duplication Syndrome

  • 17p13.3 Microduplication Syndrome

  • Trisomy 17p13.3

  • Chromosome 17p13.3 Centromeric Duplication Syndrome

  • Dup(17)(P13.3)

Neuronopathy, Distal Hereditary Motor, Type Viib
  • HMN7B

  • Hmn Viib

  • Dhmn7b

  • Neuropathy, Distal Hereditary Motor, Type Viib

  • Distal Hereditary Motor Neuronopathy Type 7b

  • Distal Hereditary Motor Neuropathy Type Viib

  • Neuronopathy, Distal Hereditary Motor, Type 7b

  • Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

  • Lower Motor Neuron Disease, Dynactin Type

  • Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

  • Harper-Young Myopathy

  • Neuronopathy, Distal Hereditary Motor, 7b

  • Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

  • Lower Motor Neuron Disease Dynactin Type

  • Plmnd

  • Progressive Lower Motor Neuron Disease

  • Neuropathy, Motor, Distal, Hereditary, Type Viib

Band Heterotopia
  • Subcortical Band Heterotopia

  • Double Cortex Syndrome

  • Subcortical Laminar Heterotopia

  • Double Cortex

  • Band Heterotopia Of Brain

  • BH

  • Heco

  • Heterotopic Cortex

  • Familial Band Heterotopia

  • Dc

  • Dc Syndrome

  • Heterotopia, Subcortical Band

  • Sbh

  • Sclh

  • Bhy

Bipolar Disorder
  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Autism
  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic

Congenital Nervous System Abnormality
  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder

Psychotic Disorder
  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders

Periventricular Nodular Heterotopia
  • Periventricular Heterotopia

  • Pvnh

  • Familial Nodular Heterotopia

  • Heterotopia, Periventricular

  • Periventricular Heterotopia, X-Linked

Primary Autosomal Recessive Microcephaly
  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus NDEL1 VGNC VGNC:31933
Rattus norvegicus NDEL1 RGD RGD:621235
Canis familiaris NDEL1 VGNC VGNC:43672
Mus musculus NDEL1 MGD MGI:1932915
Macaca mulatta NDEL1 VGNC VGNC:74982
Felis catus NDEL1 VGNC VGNC:63749
Others NDEL1 NCBI