NDEL1 Antibody (YA3094)
(Synonyms: EOPA; MITAP1; NDEL1; NUDEL)NDEL1 Antibody (YA3094) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NDEL1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NDEL1 Antibody (YA3094) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NDEL1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 38 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Entrez Gene: 81565 Human ; 83431 Mouse ;
SwissProt: Q9GZM8 Human ; Q9ERR1 Mouse ;
OMIM: 607538 Human
A synthetic peptide of human NDEL1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NDEL1 is required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Plays a role, together with DISC1, in the regulation of neurite outgrowth. May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network[1].
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Subcellular Localization
Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle
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Expression
Tissue_specificity:It is expressed in the brain, heart, kidneys, liver, lungs, pancreas, placenta, and skeletal muscle. -
Isoforms & Post-Translational Modification
Q9GZM8 has 3 isomers: Q9GZM8-1: 38375 Da (predicted); Q9GZM8-2: 40616 Da (predicted); Q9GZM8-3: 37039 Da (predicted).
Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE;Palmitoylation at Cys-273 reduces affinity for dynein -
Subunit
Interacts with ZNF365. Interacts with GTP-bound RAB9A; the interaction may lead to RAB9A-dynein motor tethering (PubMed:34793709)
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SwissProt ID
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Synonyms
EOPA; MITAP1; NDEL1; NUDEL
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Research Field
Neuroscience
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