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54462

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By Targets:	Apoptosis (1) Bcl-2 Family (2) CaSR (2) Cytochrome P450 (2) Histone Methyltransferase (1) LPL Receptor (3) MicroRNA (4) Monoamine Oxidase (2) PARP (2) Reference Standards (1) RXFP Receptor (1) Sodium Channel (1) Survivin (2) Thyroid Hormone Receptor (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (6)
Oligonucleotides:	miRNA mimics (1) miRNA antagomirs (1) miRNA agomirs (1) MicroRNAs (4) miRNA inhibitors (1)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148087

AZD5462 1 Publications Verification	RXFP Receptor	Cardiovascular Disease
AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties .

HY-150190

F5446 1 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo .

HY-14401

Encaleret CLTX-305; JTT-305; MK-5442	CaSR Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC₅₀ of 12 nM. Encaleret exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1 .

HY-W008634

Bropirimine 2 Publications Verification U-54461; U-54461S; PNU-54461	Toll-like Receptor (TLR)	Cancer
Bropirimine (U-54461; U-54461S; PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs). Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis .

HY-10968

CYM5442 3 Publications Verification	LPL Receptor	Neurological Disease
CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .

HY-B1311

Proadifen hydrochloride 1 Publications Verification SKF-525A; U-5446; RP-5171	Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC₅₀ value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases .

HY-157786

XPC-5462	Sodium Channel	Neurological Disease
XPC-5462 is a selective Na_V1.6/1.2 inhibitor, with an IC₅₀ of 0.0103 μM against hNa_V1.6, 0.0137 μM against mNa_V1.6, and 0.0109 μM against hNa_V1.2. XPC-5462 significantly reduces epileptiform discharges. XPC-5462 is applicable for epilepsy-related research .

HY-10968A

CYM5442 hydrochloride	LPL Receptor	Neurological Disease
CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS) .

HY-10968R

CYM5442 (Standard)	LPL Receptor	Neurological Disease
CYM5442 (Standard) is the analytical standard of CYM5442. This product is intended for research and analytical applications. CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .

HY-R01066A

*hsa-miR-4462* agomir**	MicroRNA	Cancer
hsa-miR-4462 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4462 agomir hsa-miR-4462 agomir

HY-R01066

*hsa-miR-4462* mimic**	MicroRNA	Cancer
hsa-miR-4462 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-4462 mimic hsa-miR-4462 mimic

HY-B1311R

Proadifen hydrochloride (Standard) SKF-525A (Standard); U-5446 (Standard); RP-5171 (Standard)	Reference Standards Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (hydrochloride) (Standard) is the analytical standard of Proadifen (hydrochloride). This product is intended for research and analytical applications. Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases [4] .

HY-RI01066

*hsa-miR-4462* inhibitor**	MicroRNA	Cancer
hsa-miR-4462 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-4462 inhibitor hsa-miR-4462 inhibitor

HY-RI01066A

*hsa-miR-4462* antagomir**	MicroRNA	Cancer
hsa-miR-4462 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4462 antagomir hsa-miR-4462 antagomir

HY-14401B

Encaleret sodium CLTX-305 sodium; JTT-305 sodium; MK-5442 sodium	CaSR Thyroid Hormone Receptor	Metabolic Disease
Encaleret (CLTX-305) sodium is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC₅₀ of 12 nM. Encaleret sodium exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret sodium can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1 .

Host:	Mouse (10) Rabbit (2)
Reactivity:	Human (12) Rat (4) Mouse (6)
Application:	IHC-P (4) ICC/IF (6) IP (3) WB (7) FC (4) ELISA (5)
Isotype:	IgG (2) IgG1 (3) IgG2a (1) IgG2b (3)
Conjugation:	Non-conjugated (12)
Clonality:	Monoclonal (9) Recombinant (1)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85770

	ERK 1/2 Antibody (YA5462) MAPK1/MAPK3	WB, ICC/IF, ELISA	Human, Mouse, Rat
	ERK 1/2 Antibody (YA5462) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERK 1/2.

HY-P85754

	S6K1 Antibody (YA5446) RPS6KB1	IHC-P, ICC/IF	Human, Rat, Mouse
	S6K1 Antibody (YA5446) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to S6K1.

HY-P84765

	Nucleostemin Antibody (YA4462) NS; E2IG3; NNP47; C77032	WB, FC, ELISA	Human, Mouse
	Nucleostemin Antibody (YA4462) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nucleostemin.

HY-P84765A

	Nucleostemin Antibody (YA4462)(PBS only) NS; E2IG3; NNP47; C77032	WB, FC, ELISA	Human, Mouse
	Nucleostemin Antibody (YA4462) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nucleostemin.

HY-P84541

	Ikaros Antibody (YA4238) IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452	ICC/IF, FC, ELISA	Human
	Ikaros Antibody (YA4238) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Ikaros.

HY-P84541A

	Ikaros Antibody (YA4238)(PBS only) IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452	ICC/IF, FC, ELISA	Human
	Ikaros Antibody (YA4238) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Ikaros.

HY-P87286

	Kindlin 2 Antibody (YA6969) FLJ34213 antibody; FLJ44462 antibody; UNC112 antibody; FERM2_HUMAN antibody; Fermitin family homolog 2 antibody; Fermt2 antibody; KIND2 antibody; Kindlin-2 antibody; MIG-2 antibody; MIG2 antibody	WB, ICC/IF, IP	Human, Mouse, Rat
	Kindlin 2 Antibody (YA6969) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Kindlin 2.

HY-P85750

	HIF1 beta Antibody (YA5442) ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	HIF1 beta Antibody (YA5442) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HIF1 beta.

HY-P81282

	Ikaros Antibody (YA987) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	WB, IP	Human
	Ikaros Antibody (YA987) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ikaros.

HY-P81282A

	Ikaros Antibody (YA988) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ikaros.

HY-P85524

	Ikaros(C-term) Antibody (YA5216) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros; zinc finger protein; IKAROS; IKAROS family zinc finger 1; Ikaros; Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1; Ikaros; zinc finger protein subfamily 1A 1; Zinc finger protein, subfamily 1A, member 1; ZNFN1A1.	WB, IP	Human
	Ikaros(C-term) Antibody (YA5216) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ikaros(C-term).

HY-P81282AA

	Ikaros Antibody (YA988)(PBS only) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ikaros.

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Cat. No.	Product Name		Classification

HY-R01066A

*hsa-miR-4462* agomir**		MicroRNAs miRNA agomirs
hsa-miR-4462 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01066

*hsa-miR-4462* mimic**		MicroRNAs miRNA mimics
hsa-miR-4462 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01066

*hsa-miR-4462* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-4462 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01066A

*hsa-miR-4462* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-4462 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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