Nucleostemin Antibody (YA4462)
(Synonyms: NS; E2IG3; NNP47; C77032)Based on 1 Customer Validation
Nucleostemin Antibody (YA4462) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nucleostemin.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
Nucleostemin Antibody (YA4462) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nucleostemin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 62 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 62 kDa
Purified recombinant fragment of human GNL3 (AA: 1-226) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nucleostemin may be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation
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Subcellular Localization
Nucleus; Nucleus, nucleolus
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Expression
Tissue_specificity:The level of this substance is elevated in cancerous lung tissue. -
Isoforms & Post-Translational Modification
Q9BVP2 has 2 isomers: Q9BVP2-1: 61993 Da (predicted); Q9BVP2-2: 60540 Da (predicted).
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Subunit
Interacts with MDM2; this interaction stabilizes MDM2 (By similarity). Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (PubMed:12464630). Interacts with TSC22D1 isoform 2 (PubMed:34681573)
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SwissProt ID
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Synonyms
NS; E2IG3; NNP47; C77032
Documentation
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