GNL3 - G protein nucleolar 3 Gene

Also Known as NS; E2IG3; NNP47; C77032

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26354

About GNL3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,685,920-52,694,497 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 6 paralogues. Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues.

Summary

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GNL3 Products (3)

mRNA Protein Name
NM_014366.5 NP_055181.3 guanine nucleotide-binding protein-like 3 isoform 1
NM_206825.2 NP_996561.1 guanine nucleotide-binding protein-like 3 isoform 2
NM_206826.1 NP_996562.1 guanine nucleotide-binding protein-like 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
16213212 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16097049 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
25569094 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
22641345 GOA
involved in positive regulation of protein sumoylation IMP
IMP: Inferred from mutant phenotype
22641345 GOA
involved in positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
22641345 GOA
involved in stem cell division IDA
IDA: Inferred from direct assay
25522312 GOA
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
25522312 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
22641345 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNL3 Protein Structure

GN3L_Grn1

GN3L_Grn1: GNL3L/Grn1 putative GTPase (16 - 91)

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (256 - 314)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein-like 3

  • E2-induced gene 3 protein

GNL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNL3 Q9BVP2 TERT Homo sapiens O14746
IF
24550003
Intra
GNL3 Q9BVP2 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
24550003
Intra
GNL3 Q9BVP2 PPP2R5A Homo sapiens Q15172
Y2H
16097049
Intra
GNL3 Q9BVP2 CEP19 Homo sapiens Q96LK0
Y2H Array
32296183
Intra
GNL3 Q9BVP2 CEP19 Homo sapiens Q96LK0
Y2H Prey Pooling
32296183
Intra
GNL3 Q9BVP2 NLE1 Homo sapiens Q9NVX2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

GNL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82173 Nucleostemin Antibody (YA1918) WB, ICC/IF, FC Human
HY-P84765 Nucleostemin Antibody (YA4462) WB, FC, ELISA Human, Mouse
HY-P84765A Nucleostemin Antibody (YA4462)(PBS only) WB, FC, ELISA Human, Mouse

Related Diseases

Diseases Alias
Tibial Adamantinoma

  • Tibial Adamantinoma Morphology
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05566 GNL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05567 GNL3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GNL3 VGNC VGNC:73038
Canis familiaris GNL3 VGNC VGNC:41327
Rattus norvegicus GNL3 RGD RGD:631354
Felis catus GNL3 VGNC VGNC:62626
Bos taurus GNL3 VGNC VGNC:29473
Mus musculus GNL3 MGD MGI:1353651
Others GNL3 NCBI