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GNL3 - G protein nucleolar 3 Gene

Also Known as NS; E2IG3; NNP47; C77032

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 26354

About GNL3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,685,920-52,694,497 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 6 paralogues. Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues.

Summary

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GNL3 Products (3)

mRNA	Protein	Name
NM_014366.5	NP_055181.3	guanine nucleotide-binding protein-like 3 isoform 1
NM_206825.2	NP_996561.1	guanine nucleotide-binding protein-like 3 isoform 2
NM_206826.1	NP_996562.1	guanine nucleotide-binding protein-like 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16097049	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	25569094	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in positive regulation of protein sumoylation	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in stem cell division	IDA IDA: Inferred from direct assay	25522312	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	25522312	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in nucleolus	IDA IDA: Inferred from direct assay	22641345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNL3 Protein Structure

GN3L_Grn1

MMR_HSR1

0
100
200
300
400
500
549 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein-like 3	E2-induced gene 3 protein

GNL3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GNL3	Q9BVP2	TERT	Homo sapiens	O14746	IF	24550003
Intra	GNL3	Q9BVP2	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	24550003
Intra	GNL3	Q9BVP2	PPP2R5A	Homo sapiens	Q15172	Y2H	16097049
Intra	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Array	32296183
Intra	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	32296183
Intra	GNL3	Q9BVP2	NLE1	Homo sapiens	Q9NVX2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

GNL3 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82173	Nucleostemin Antibody (YA1918)	WB, ICC/IF, FC	Human
HY-P84765	Nucleostemin Antibody (YA4462)	WB, FC, ELISA	Human, Mouse
HY-P84765A	Nucleostemin Antibody (YA4462)(PBS only)	WB, FC, ELISA	Human, Mouse

関連疾患

Diseases	Alias
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05566	GNL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05567	GNL3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	GNL3	VGNC	VGNC:73038
Canis familiaris	GNL3	VGNC	VGNC:41327
Rattus norvegicus	GNL3	RGD	RGD:631354
Felis catus	GNL3	VGNC	VGNC:62626
Bos taurus	GNL3	VGNC	VGNC:29473
Mus musculus	GNL3	MGD	MGI:1353651
Others	GNL3	NCBI