TERT - telomerase reverse transcriptase Gene
Also Known as TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
Species: Homo sapiens
About TERT
This gene has 7 transcripts (splice variants), 188 orthologues and is associated with 125 phenotypes. Low expression observed in reference dataset.
Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with Reverse Transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of Telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that Telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase Reverse Transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of Telomerase activity. [provided by RefSeq, Jul 2008]
TERT Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_198253.3 | NP_937983.2 | telomerase reverse transcriptase isoform 1 |
| NM_001193376.3 | NP_001180305.1 | telomerase reverse transcriptase isoform 2 |
| NM_198254.1 | ||
| NR_149163.3 | ||
| NM_198255.2 | ||
| NR_149162.3 |
TERT Protein Structure
Telomerase_RBD: Telomerase ribonucleoprotein complex - RNA binding domain (459 - 593)
RVT_1: Reverse transcriptase (RNA-dependent DNA polymerase) (701 - 905)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1132 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
telomerase reverse transcriptase |
|
TERT Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TERT | O14746 | SMARCA4 | Homo sapiens | P51532 | 19571879 | |
|
Intra
|
TERT | O14746 | SMARCA4 | Homo sapiens | P51532 | 19571879 | |
|
Intra
|
TERT | O14746 | SMARCA4 | Homo sapiens | P51532 | 24550003 | |
|
Intra
|
TERT | O14746 | SMARCA4 | Homo sapiens | P51532 | 24550003 | |
|
Intra
|
TERT | O14746 | PML | Homo sapiens | P29590-5 | 19567472 | |
|
Intra
|
TERT | O14746 | PML | Homo sapiens | P29590-5 | 19567472 | |
|
Intra
|
TERT | O14746 | PML | Homo sapiens | P29590-5 | 19567472 | |
|
Intra
|
TERT | O14746 | RUVBL1 | Homo sapiens | Q9Y265 | 18358808 | |
|
Intra
|
TERT | O14746 | RUVBL1 | Homo sapiens | Q9Y265 | 18358808 | |
|
Intra
|
TERT | O14746 | UPF1 | Homo sapiens | Q92900 | 21829167 | |
|
Intra
|
TERT | O14746 | CTNNB1 | Homo sapiens | P35222 | 19571879 | |
|
Intra
|
TERT | O14746 | CTNNB1 | Homo sapiens | P35222 | 19571879 | |
|
Intra
|
TERT | O14746 | GNL3 | Homo sapiens | Q9BVP2 | 24550003 | |
|
Intra
|
TERT | O14746 | GNL3 | Homo sapiens | Q9BVP2 | 24550003 | |
|
Intra
|
TERT | O14746 | PINX1 | Homo sapiens | Q96BK5 | 15381700 | |
|
Intra
|
TERT | O14746 | PINX1 | Homo sapiens | Q96BK5 | 28255170 | |
|
Intra
|
TERT | O14746 | NPM1 | Homo sapiens | P06748 | 28255170 |
TERT Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81110 | TERT Antibody | WB, ELISA, IHC-P, IHC-F, FC, ICC/IF, | Human, Mouse, Rat, |
| HY-P81110A | TERT Antibody (YA3439) | WB | Human |
| HY-P83807 | TERT Antibody (YA3504) | IHC-P, FC, ELISA | Human |
| HY-P83807A | TERT Antibody (YA3504)(PBS only) | IHC-P, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Giant Cell Glioblastoma |
|
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| Lymphoid Interstitial Pneumonia |
|
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| Diffuse Glioma, H3 G34 Mutant |
|
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| Intraventricular Meningioma |
|
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| Ameloblastoma |
|
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| Pulmonary Fibrosis |
|
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| Pancytopenia |
|
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| Chromophobe Renal Cell Carcinoma |
|
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| Lung Cancer Susceptibility 3 |
|
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| Nodular Malignant Melanoma |
|
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| Wilms Tumor 1 |
|
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| Rhabdomyosarcoma |
|
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| Spitzoid Melanoma |
|
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| Anaplastic Oligodendroglioma |
|
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| Cholangiocarcinoma |
|
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| Diamond-Blackfan Anemia |
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| High Grade Glioma |
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| T-Cell Acute Lymphoblastic Leukemia |
|
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| Pheochromocytoma |
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| Interstitial Lung Disease |
|
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| Meningioma, Familial |
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| Myeloid Leukemia |
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| Hepatoblastoma |
|
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| Eye Disease |
|
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| Leukemia, Acute Myeloid |
|
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| Skull Base Cancer |
|
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| Hepatocellular Carcinoma |
|
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| Thrombocytopenia |
|
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| Lung Benign Neoplasm |
|
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| Melanoma |
|
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| Bladder Papillary Transitional Cell Neoplasm |
|
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| Gastric Cancer |
|
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| Mixed Oligodendroglioma-Astrocytoma |
|
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| Low Grade Glioma |
|
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| Rhabdoid Meningioma |
|
|
| Hoyeraal Hreidarsson Syndrome |
|
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| Dyskeratosis Congenita, Autosomal Dominant 1 |
|
|
| Macrocytic Anemia |
|
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| Anaplastic Astrocytoma |
|
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| Nasopharyngeal Carcinoma |
|
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| Nonencapsulated Sclerosing Carcinoma |
|
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| Thyroid Gland Cancer |
|
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| Colorectal Cancer |
|
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| Basal Cell Carcinoma |
|
|
| Cartilage-Hair Hypoplasia |
|
|
| Tangier Disease |
|
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| Benign Meningioma |
|
|
| Spinal Cord Disease |
|
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| Breast Cancer |
|
|
| Beta-Thalassemia |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Lynch Syndrome |
|
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| Liver Benign Neoplasm |
|
|
| Diffuse Astrocytoma |
|
|
| Thyroid Gland Follicular Carcinoma |
|
|
| Conjunctival Cancer |
|
|
| Melanoma, Uveal |
|
|
| Differentiated Thyroid Carcinoma |
|
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| Cystitis Cystica |
|
|
| Anaplastic Pleomorphic Xanthoastrocytoma |
|
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| Bladder Transitional Cell Papilloma |
|
|
| Kidney Clear Cell Sarcoma |
|
|
| Nijmegen Breakage Syndrome |
|
|
| Conjunctival Nevus |
|
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| Skull Base Meningioma |
|
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| Melanoma, Cutaneous Malignant 1 |
|
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| Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 1 |
|
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| Shwachman-Diamond Syndrome 1 |
|
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| Lung Cancer |
|
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| Gestational Trophoblastic Neoplasm |
|
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| Idh-Wildtype Glioblastoma |
|
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| Meningothelial Meningioma |
|
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| Nervous System Disease |
|
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| Idh-Wildtype Anaplastic Astrocytoma |
|
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| Interstitial Lung Disease 2 |
|
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| Medulloblastoma |
|
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| Adult Spinal Cord Glioblastoma Multiforme |
|
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| Mixed Glioma |
|
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| Non-Invasive Bladder Papillary Urothelial Neoplasm |
|
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| Brain Cancer |
|
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| Prostate Cancer |
|
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| Bladder Cancer |
|
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| Malignant Peripheral Nerve Sheath Tumor |
|
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| Ovarian Cancer |
|
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| Myelodysplastic Syndrome |
|
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| Dyskeratosis Congenita, Autosomal Dominant 2 |
|
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| Endometrial Cancer |
|
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| Microscopic Polyangiitis |
|
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| Urinary Tract Papillary Transitional Cell Benign Neoplasm |
|
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| Herpes Zoster |
|
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| Squamous Cell Carcinoma |
|
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| Cecum Adenoma |
|
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| Spinal Cancer |
|
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| Joubert Syndrome 21 |
|
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| Testicular Germ Cell Cancer |
|
|
| Ureter, Cancer Of |
|
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| Mucosal Melanoma |
|
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| Gallbladder Cancer |
|
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| Larynx Cancer |
|
|
| Aplastic Anemia |
|
|
| Dyskeratosis Congenita |
|
|
| Alpha-Thalassemia |
|
|
| Brain Glioma |
|
|
| Thyroid Sarcoma |
|
|
| Hepatocellular Adenoma |
|
|
| Basal Cell Nevus Syndrome |
|
|
| Peripheral Nervous System Disease |
|
|
| Dyskeratosis Congenita Autosomal Recessive |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Pilocytic Astrocytoma |
|
|
| Clear Cell Meningioma |
|
|
| Pancreatic Cancer |
|
|
| Dyskeratosis Congenita, Autosomal Recessive 1 |
|
|
| Pleomorphic Xanthoastrocytoma |
|
|
| Cecal Benign Neoplasm |
|
|
| Oligodendroglioma |
|
|
| Dyskeratosis Congenita, X-Linked |
|
|
| Gastroesophageal Reflux |
|
|
| Glioblastoma |
|
|
| Retinitis Pigmentosa |
|
|
| Revesz Syndrome |
|
|
| Skin Disease |
|
|
| Bladder Small Cell Carcinoma |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Malignant Conjunctival Melanoma |
|
|
| Melanoma, Cutaneous Malignant 9 |
|
|
| Tongue Carcinoma |
|
|
| Idiopathic Interstitial Pneumonia |
|
|
| Acral Lentiginous Melanoma |
|
|
| Li-Fraumeni Syndrome |
|
|
| Temporal Lobe Neoplasm |
|
|
| Paratesticular Lipoma |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Esophageal Cancer |
|
|
| Gliosarcoma |
|
|
| Cervical Intraepithelial Neoplasia |
|
|
| Idh-Mutant Glioblastoma |
|
|
| Osteoporosis |
|
|
| Cri-Du-Chat Syndrome |
|
|
| Tall Cell Variant Papillary Carcinoma |
|
|
| Neuroblastoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | TERT | MGD | MGI:1202709 |
| Bos taurus | TERT | VGNC | VGNC:35751 |
| Canis familiaris | TERT | VGNC | VGNC:47255 |
| Rattus norvegicus | TERT | RGD | RGD:70494 |
| Felis catus | TERT | VGNC | VGNC:66086 |
| Macaca mulatta | TERT | VGNC | VGNC:78313 |
| Others | TERT | NCBI |