Tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate
Based on 1 Customer Validation
Tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- CAS No.: 169457-73-2
- Formula: C12H22BrNO2
- Molecular Weight:292.22
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E976 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 169457-73-2
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Appearance Solid
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Molecular Weight 292.22
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Formula C12H22BrNO2
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SMILES
O=C(OC(C)(C)C)N1CCC(CCBr)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (342.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4221 mL | 17.1104 mL | 34.2208 mL | 85.5520 mL |
| 5 mM | 0.6844 mL | 3.4221 mL | 6.8442 mL | 17.1104 mL | |
| 10 mM | 0.3422 mL | 1.7110 mL | 3.4221 mL | 8.5552 mL | |
| 15 mM | 0.2281 mL | 1.1407 mL | 2.2814 mL | 5.7035 mL | |
| 20 mM | 0.1711 mL | 0.8555 mL | 1.7110 mL | 4.2776 mL | |
| 25 mM | 0.1369 mL | 0.6844 mL | 1.3688 mL | 3.4221 mL | |
| 30 mM | 0.1141 mL | 0.5703 mL | 1.1407 mL | 2.8517 mL | |
| 40 mM | 0.0856 mL | 0.4278 mL | 0.8555 mL | 2.1388 mL | |
| 50 mM | 0.0684 mL | 0.3422 mL | 0.6844 mL | 1.7110 mL | |
| 60 mM | 0.0570 mL | 0.2852 mL | 0.5703 mL | 1.4259 mL | |
| 80 mM | 0.0428 mL | 0.2139 mL | 0.4278 mL | 1.0694 mL | |
| 100 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8555 mL |
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