tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate
Based on 1 Customer Validation
tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : ≥98.0%
- CAS No.: 1356476-27-1
- Formula: C14H25NO3
- Molecular Weight:255.36
-
Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
![tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w056604.gif "Click to View tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
-
![Boc-(7-Azaspiro[3.5]nonane)-NH2](https://file.medchemexpress.com/product_pic/hy-w022388.gif)
HY-W022388
Boc-(7-Azaspiro[3.5]nonane)-NH2PROTAC Linker -
![2-Boc-2-Azaspiro[3.3]heptane-OH](https://file.medchemexpress.com/product_pic/hy-20236.gif)
HY-20236
2-Boc-2-Azaspiro[3.3]heptane-OHPROTAC Linker -
![tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-20238.gif)
HY-20238
tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylatePROTAC Linker -
![8-Boc-2,8-Diazaspiro[4.5]decane](https://file.medchemexpress.com/product_pic/hy-waa0067.gif)
HY-WAA0067
8-Boc-2,8-Diazaspiro[4.5]decanePROTAC Linker -
![tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate](https://file.medchemexpress.com/product_pic/hy-w043503.gif)
HY-W043503
tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylatePROTAC Linker -
![tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w052528.gif)
HY-W052528
tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylatePROTAC Linker -
![2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-21123.gif)
HY-21123
2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acidPROTAC Linker -
![7-(Tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w021171.gif)
HY-W021171
7-(Tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acidPROTAC Linker -
![Methyl 6-oxospiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w057067.gif)
HY-W057067
Methyl 6-oxospiro[3.3]heptane-2-carboxylatePROTAC Linker -
![tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate](https://file.medchemexpress.com/product_pic/hy-20239.gif)
HY-20239
tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamatePROTAC Linker -
![tert-Butyl (6-oxospiro[3.3]heptan-2-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w056040.gif)
HY-W056040
tert-Butyl (6-oxospiro[3.3]heptan-2-yl)carbamatePROTAC Linker -
![3-Benzyl-3,9-diazaspiro[5.5]undecane](https://file.medchemexpress.com/product_pic/hy-30534.gif)
HY-30534
3-Benzyl-3,9-diazaspiro[5.5]undecanePROTAC Linker
All PROTAC Linkers Isoforms
More
Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E919 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS No. 1356476-27-1
-
Appearance Solid
-
Molecular Weight 255.36
-
Formula C14H25NO3
-
Color White to off-white
-
SMILES
O=C(OC(C)(C)C)N1CCC2(CC1)CC(CO)C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (391.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (241 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9160 mL | 19.5802 mL | 39.1604 mL | 97.9010 mL |
| 5 mM | 0.7832 mL | 3.9160 mL | 7.8321 mL | 19.5802 mL | |
| 10 mM | 0.3916 mL | 1.9580 mL | 3.9160 mL | 9.7901 mL | |
| 15 mM | 0.2611 mL | 1.3053 mL | 2.6107 mL | 6.5267 mL | |
| 20 mM | 0.1958 mL | 0.9790 mL | 1.9580 mL | 4.8951 mL | |
| 25 mM | 0.1566 mL | 0.7832 mL | 1.5664 mL | 3.9160 mL | |
| 30 mM | 0.1305 mL | 0.6527 mL | 1.3053 mL | 3.2634 mL | |
| 40 mM | 0.0979 mL | 0.4895 mL | 0.9790 mL | 2.4475 mL | |
| 50 mM | 0.0783 mL | 0.3916 mL | 0.7832 mL | 1.9580 mL | |
| 60 mM | 0.0653 mL | 0.3263 mL | 0.6527 mL | 1.6317 mL | |
| 80 mM | 0.0490 mL | 0.2448 mL | 0.4895 mL | 1.2238 mL | |
| 100 mM | 0.0392 mL | 0.1958 mL | 0.3916 mL | 0.9790 mL |
tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate Related Classifications
HY-W056604 Related Classifications
Powered by Bioz