4-(tert-Butyldimethylsilyloxy)-1-butyne
Based on 1 Customer Validation
4-(tert-Butyldimethylsilyloxy)-1-butyne is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 99.61%
- CAS No.: 78592-82-2
- Formula: C10H20OSi
- Molecular Weight:184.35
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E358 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 78592-82-2
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Appearance Liquid
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Molecular Weight 184.35
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Formula C10H20OSi
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Color Colorless to light yellow
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SMILES
C#CCCO[Si](C)(C)C(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (1084.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4245 mL | 27.1223 mL | 54.2446 mL | 135.6116 mL |
| 5 mM | 1.0849 mL | 5.4245 mL | 10.8489 mL | 27.1223 mL | |
| 10 mM | 0.5424 mL | 2.7122 mL | 5.4245 mL | 13.5612 mL | |
| 15 mM | 0.3616 mL | 1.8082 mL | 3.6163 mL | 9.0408 mL | |
| 20 mM | 0.2712 mL | 1.3561 mL | 2.7122 mL | 6.7806 mL | |
| 25 mM | 0.2170 mL | 1.0849 mL | 2.1698 mL | 5.4245 mL | |
| 30 mM | 0.1808 mL | 0.9041 mL | 1.8082 mL | 4.5204 mL | |
| 40 mM | 0.1356 mL | 0.6781 mL | 1.3561 mL | 3.3903 mL | |
| 50 mM | 0.1085 mL | 0.5424 mL | 1.0849 mL | 2.7122 mL | |
| 60 mM | 0.0904 mL | 0.4520 mL | 0.9041 mL | 2.2602 mL | |
| 80 mM | 0.0678 mL | 0.3390 mL | 0.6781 mL | 1.6951 mL | |
| 100 mM | 0.0542 mL | 0.2712 mL | 0.5424 mL | 1.3561 mL |
4-(tert-Butyldimethylsilyloxy)-1-butyne Related Classifications
HY-W111872 Related Classifications
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