tert-Butyl 5-bromoisoindoline-2-carboxylate
Based on 1 Customer Validation
tert-Butyl 5-bromoisoindoline-2-carboxylate (Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate) is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
For research use only. We do not sell to patients.
- Purity : 99.44%
- CAS No.: 201940-08-1
- Formula: C13H16BrNO2
- Molecular Weight:298.18
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 201940-08-1
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Appearance Solid
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Molecular Weight 298.18
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Formula C13H16BrNO2
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Color White to off-white
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SMILES
CC(C)(OC(N1CC2=CC=C(Br)C=C2C1)=O)C
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Synonyms
Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (335.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3537 mL | 16.7684 mL | 33.5368 mL | 83.8420 mL |
| 5 mM | 0.6707 mL | 3.3537 mL | 6.7074 mL | 16.7684 mL | |
| 10 mM | 0.3354 mL | 1.6768 mL | 3.3537 mL | 8.3842 mL | |
| 15 mM | 0.2236 mL | 1.1179 mL | 2.2358 mL | 5.5895 mL | |
| 20 mM | 0.1677 mL | 0.8384 mL | 1.6768 mL | 4.1921 mL | |
| 25 mM | 0.1341 mL | 0.6707 mL | 1.3415 mL | 3.3537 mL | |
| 30 mM | 0.1118 mL | 0.5589 mL | 1.1179 mL | 2.7947 mL | |
| 40 mM | 0.0838 mL | 0.4192 mL | 0.8384 mL | 2.0960 mL | |
| 50 mM | 0.0671 mL | 0.3354 mL | 0.6707 mL | 1.6768 mL | |
| 60 mM | 0.0559 mL | 0.2795 mL | 0.5589 mL | 1.3974 mL | |
| 80 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0480 mL | |
| 100 mM | 0.0335 mL | 0.1677 mL | 0.3354 mL | 0.8384 mL |
tert-Butyl 5-bromoisoindoline-2-carboxylate Related Classifications
HY-W003696 Related Classifications
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