PTOTAC HSD17B13 degrader 1
PTOTAC HSD17B13 degrader 1 is a HSD17B13 PROTAC degrader with a DC50 of 0.11 nM. HSD17B13 is a liver lipid droplet-associated medium-chain dehydrogenase/retinol dehydrogenase. PTOTAC HSD17B13 degrader 1 can be used in liver cancer research.
(Pink: HSD17B13 ligand (HY-159662); Blue: Cereblon ligand (HY-159660); Black: linker (HY-W003696)).
For research use only. We do not sell to patients.
- CAS No.: 3046195-01-8
- Formula: C45H45ClF3N7O5
- Molecular Weight:856.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HSD17B13[1]
PTOTAC HSD17B13 degrader 1 (Example 1) can achieve sub-nanomolar level HSD17β13 degradation in Huh7 cells, with a DC50 of 0.11 nM and a Dmax of 87%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3046195-01-8
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Molecular Weight 856.33
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Formula C45H45ClF3N7O5
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(CCCN4CC5=CC(C6=CC7=NN([C@@H]8CC[C@H](CC8)CNC(C9=C(C(F)=C(C(F)=C9)O)F)=O)C=C7C=C6)=CC=C5C4)C=C3N1C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PTOTAC HSD17B13 degrader 1 Related Classifications
HY-159651 Related Classifications
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