Methacrylic anhydride
Based on 1 publication(s) in Google Scholar
Methacrylic anhydride is a typical polymerizable 1,6-diolefin. Methacrylic anhydride can form a soluble csyclopolymer by free-radical initiation. Methacrylic anhydride can spontaneously polymerize through the vinyl group and justifies the use of 2-6-di-tert-butyl4-methylphenol as an inhibitor.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 760-93-0
- Formula: C8H10O3
- Molecular Weight:154.17
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Methacrylic anhydride
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Biological Activity
Methacrylic anhydride is cross-linked with EGDMA to form copolymer, and can be used for synthesis of pH sensitive hydrogel microcapsules for drug delivery system[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 760-93-0
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Appearance Liquid (Density: 1.035 g/cm3)
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Molecular Weight 154.17
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Formula C8H10O3
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Color Colorless to light yellow
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SMILES
CC(C(OC(C(C)=C)=O)=O)=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
GelMA Hydrogel as a Promising Delivery System for Osthole in the Treatment of Rheumatoid Arthritis: Targeting the miR-1224-3p/AGO1 Axis. [Abstract]2023 Aug 25;24(17):13210. PMID: 37686018
Solvent & Solubility
DMSO : 100 mg/mL (648.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (618 KB)
- English - EN (618 KB)
- Français - FR (618 KB)
- Deutsch - DE (618 KB)
- Norwegian - NO (618 KB)
- Español - ES (618 KB)
- Swedish - SV (618 KB)
- Italian - IT (618 KB)
- Korean - KR (618 KB)
- Portuguese - PT (618 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.4863 mL | 32.4317 mL | 64.8635 mL | 162.1587 mL |
| 5 mM | 1.2973 mL | 6.4863 mL | 12.9727 mL | 32.4317 mL | |
| 10 mM | 0.6486 mL | 3.2432 mL | 6.4863 mL | 16.2159 mL | |
| 15 mM | 0.4324 mL | 2.1621 mL | 4.3242 mL | 10.8106 mL | |
| 20 mM | 0.3243 mL | 1.6216 mL | 3.2432 mL | 8.1079 mL | |
| 25 mM | 0.2595 mL | 1.2973 mL | 2.5945 mL | 6.4863 mL | |
| 30 mM | 0.2162 mL | 1.0811 mL | 2.1621 mL | 5.4053 mL | |
| 40 mM | 0.1622 mL | 0.8108 mL | 1.6216 mL | 4.0540 mL | |
| 50 mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 3.2432 mL | |
| 60 mM | 0.1081 mL | 0.5405 mL | 1.0811 mL | 2.7026 mL | |
| 80 mM | 0.0811 mL | 0.4054 mL | 0.8108 mL | 2.0270 mL | |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6216 mL |
Methacrylic anhydride Related Classifications
HY-W017330 Related Classifications
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