1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Tris(2,4-di-tert-butylphenyl)phosphate

Tris(2,4-di-tert-butylphenyl)phosphate 

Cat. No.: HY-136177 Purity: >98.0%
Handling Instructions

Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking.

For research use only. We do not sell to patients.

Tris(2,4-di-tert-butylphenyl)phosphate Chemical Structure

Tris(2,4-di-tert-butylphenyl)phosphate Chemical Structure

CAS No. : 95906-11-9

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Description

Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking[1].

IC50 & Target

sPLA2[1]

In Vivo

Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP; 50 mg/kg and 70 mg/kg) exhibits significant anti-inflammatory activity in carrageenan induced paw odema model[1].
Tris(2,4-di-tert-butylphenyl)phosphate (50 mg/kg and 70 mg/kg) reduces the raw paw odema volume significantly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

662.92

Formula

C₄₂H₆₃O₄P

CAS No.

95906-11-9

SMILES

O=P(OC1=C(C(C)(C)C)C=C(C(C)(C)C)C=C1)(OC2=C(C(C)(C)C)C=C(C(C)(C)C)C=C2)OC3=C(C(C)(C)C)C=C(C(C)(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (150.85 mM; Need ultrasonic)

DMSO : 2 mg/mL (3.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5085 mL 7.5424 mL 15.0848 mL
5 mM 0.3017 mL 1.5085 mL 3.0170 mL
10 mM 0.1508 mL 0.7542 mL 1.5085 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.77 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.77 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tris(2,4-di-tert-butylphenyl)phosphatePhospholipaseanti-inflammatorysecretorysPLA2moleculardockingInhibitorinhibitorinhibit

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Product Name:
Tris(2,4-di-tert-butylphenyl)phosphate
Cat. No.:
HY-136177
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