1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. ML348

ML348 (Synonyms: GNF-Pf-1127)

Cat. No.: HY-100736 Purity: 99.88%
Handling Instructions

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2.

For research use only. We do not sell to patients.

ML348 Chemical Structure

ML348 Chemical Structure

CAS No. : 899713-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 456 In-stock
Estimated Time of Arrival: December 31
100 mg USD 804 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].

IC50 & Target

IC 50: 210 nM (LYPLA1)

In Vitro

ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293T cells, murine T-cells
Concentration: 5 µM
Incubation Time: 3 hours
Result: Show potent, selective inhibition of LYPLA1.
In Vivo

ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 male mice (3-4 months)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 3 hours
Result: Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung in vivo.
Molecular Weight

415.79

Formula

C₁₈H₁₇ClF₃N₃O₃

CAS No.

899713-86-1

SMILES

O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4051 mL 12.0253 mL 24.0506 mL
5 mM 0.4810 mL 2.4051 mL 4.8101 mL
10 mM 0.2405 mL 1.2025 mL 2.4051 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ML348GNF-Pf-1127ML 348ML-348PhospholipaseInhibitorinhibitorinhibit

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ML348
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