2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. U-73343

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC.

For research use only. We do not sell to patients.

U-73343 Chemical Structure

U-73343 Chemical Structure

CAS No. : 142878-12-4

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Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Solid
1 mg USD 35 In-stock
5 mg USD 75 In-stock
10 mg USD 125 In-stock
50 mg USD 400 In-stock
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Based on 3 publication(s) in Google Scholar

U-73343 Related Antibodies

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Description

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC[1][2].

In Vitro

U73343, which potently inhibits acid secretion, shows no inhibitory effect on either K+-pNPPase or H+,K+-ATPase activity. U73343 dose-dependently inhibits, histamine (Hist)-, carbachol (CCh)-, and dbcAMPstimulated aminopyrine accumulation in gastric glands[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

U-73343 Related Antibodies
Molecular Weight

466.66

Formula

C29H42N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1)N(CCCCCCN[C@H]2CCC3C4CCC5=C(C=CC(OC)=C5)C4CC[C@]23C)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (7.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1429 mL 10.7144 mL 21.4289 mL
5 mM 0.4286 mL 2.1429 mL 4.2858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.39%

COA (248 KB) HNMR (275 KB) RP-HPLC (261 KB) MS (176 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1429 mL 10.7144 mL 21.4289 mL 53.5722 mL
5 mM 0.4286 mL 2.1429 mL 4.2858 mL 10.7144 mL
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U-73343 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-73343142878-12-4U73343U 73343PhospholipaseInhibitorinhibitorinhibit

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