U-73343
Based on 8 publication(s) in Google Scholar
U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 142878-12-4
- Formula: C29H42N2O3
- Molecular Weight:466.66
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) U-73343
More- Sci Signal. 2021 Dec 14;14(713):eabj4243. [Abstract]
- Eur J Pharmacol. 2025 Sep 15:1003:177900. [Abstract]
- Acta Physiol. 2023 Apr;237(4):e13926. [Abstract]
- Mol Med Rep. 2024 Jul;30(1):110. [Abstract]
- Front Biosci (Landmark Ed). 2026 Apr 23;31(4):49504. [Abstract]
- J Biol Chem. 2022 May;298(5):101847. [Abstract]
- ACS Chem Biol. 2026 Jun 12. [Abstract]
- Vaccine. 2025 Apr 30:54:127056. [Abstract]
All Phospholipase Isoforms
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Biological Activity
U73343, which potently inhibits acid secretion, shows no inhibitory effect on either K+-pNPPase or H+,K+-ATPase activity. U73343 dose-dependently inhibits, histamine (Hist)-, carbachol (CCh)-, and dbcAMPstimulated aminopyrine accumulation in gastric glands[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 142878-12-4
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Appearance Solid
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Molecular Weight 466.66
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Formula C29H42N2O3
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Color White to off-white
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SMILES
O=C(CC1)N(CCCCCCN[C@H]2CCC3C4CCC5=C(C=CC(OC)=C5)C4CC[C@]23C)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Sci Signal
Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis. [Abstract]2021 Dec 14;14(713):eabj4243. PMID: 34905385 -
Eur J Pharmacol
Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis. [Abstract]2025 Sep 15:1003:177900. PMID: 40617384 -
Acta Physiol
2023 Apr;237(4):e13926. PMID: 36606511 -
Mol Med Rep
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2+ axis. [Abstract]2024 Jul;30(1):110. PMID: 38695251 -
Front Biosci (Landmark Ed)
Annexin A5 Regulates Store-Operated Calcium Entry via Glyceraldehyde-3-Phosphate Dehydrogenase in Hepatocellular Carcinoma. [Abstract]2026 Apr 23;31(4):49504. PMID: 42052824 -
J Biol Chem
Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice. [Abstract]2022 May;298(5):101847. PMID: 35314195 -
ACS Chem Biol
2026 Jun 12. PMID: 42284103 -
Vaccine
Sensitive detection of pertussis toxin in acellular pertussis vaccines using HRH1-mediated calcium signaling. [Abstract]2025 Apr 30:54:127056. PMID: 40158234
Solvent & Solubility
DMSO : 3.33 mg/mL (7.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88. [Content Brief]
[2]. A Tatrai, et al. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim Biophys Acta. 1994 Dec 30;1224(3):575-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1429 mL | 10.7144 mL | 21.4289 mL | 53.5722 mL |
| 5 mM | 0.4286 mL | 2.1429 mL | 4.2858 mL | 10.7144 mL |
U-73343 Related Classifications
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