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Cat. No.: HY-W088749

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tert-Butyl-hexanedioic acid

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tert-Butyl-hexanedioic acid is a PROTAC linker. tert-Butyl-hexanedioic acid can be used to synthesize PROTAC molecules, such as PROTAC ERα Degrader-12 (HY-174453).

For research use only. We do not sell to patients.

Purity: 98.69%
CAS No.: 52221-07-5
Formula: C₁₀H₁₈O₄
Molecular Weight:202.25

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

tert-Butyl-hexanedioic acid Chemical Structure

CAS No.: 52221-07-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

tert-Butyl-hexanedioic acid is a PROTAC linker. tert-Butyl-hexanedioic acid can be used to synthesize PROTAC molecules, such as PROTAC ERα Degrader-12 (HY-174453)^[1].

All PROTAC Linkers Isoforms :

Chemical Information

CAS No. 52221-07-5
Appearance Liquid
Molecular Weight 202.25
Formula C₁₀H₁₈O₄
Color Colorless to light yellow
SMILES

O=C(O)CCCCC(=O)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS). J Med Chem. 2025 Jul 10;68(13):13640-13660. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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tert-Butyl-hexanedioic acid

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

tert-Butyl-hexanedioic acid Related Classifications

HY-W088749 Related Classifications