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  3. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 

Cat. No.: HY-135587
Handling Instructions

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide.

For research use only. We do not sell to patients.

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Chemical Structure

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Chemical Structure

CAS No. : 174264-46-1

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Description

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].

In Vitro

The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide[1].

Molecular Weight

587.84

Formula

C₃₄H₄₁NO₄SSi

CAS No.

174264-46-1

SMILES

O=C(C1=C(C2=CC=C(O[Si](C)(C(C)(C)C)C)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

4'-tert-Butyldimethylsilyl-6-hydroxy RaloxifeneOthersRaloxifenereactionInhibitorinhibitorinhibit

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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
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HY-135587
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