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Cat. No.: HY-135587

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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

Name: 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
Brand: MedChemExpress
SKU: HY-135587
Price: 137.00 USD
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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide.

For research use only. We do not sell to patients.

CAS No.: 174264-46-1
Formula: C₃₄H₄₁NO₄SSi
Molecular Weight:587.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Chemical Structure

CAS No.: 174264-46-1

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Description

In Vitro

The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 174264-46-1
Molecular Weight 587.84
Formula C₃₄H₄₁NO₄SSi
SMILES

O=C(C1=C(C2=CC=C(O[Si](C)(C(C)(C)C)C)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dodge JA, et al. Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):97-106. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

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Calculators

Help & FAQs

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Related Classifications

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