Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant

Name: Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant
Brand: MedChemExpress
SKU: HY-Y1883
Rating: 5.0 (24 reviews)

Cat. No.: HY-Y1883 Pureté: 99.20%: Fiche technique
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Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV.

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Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant Chemical Structure

CAS No. : 9002-93-1

Size	Stock	Quantité
Solvent
50 mL	En stock	Estimated Time of Arrival: December 31
Solvent
100 mL	En stock	Estimated Time of Arrival: December 31
Solvent
500 mL	En stock	Estimated Time of Arrival: December 31
1L	Obtenir un devis
5L	Obtenir un devis

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Based on 24 publication(s) in Google Scholar

Other Forms of Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant:

Polyethylene glycol mono(4-tert-octylphenyl) ether In-stock

24 Publications Citing Use of MCE Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant

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Description

In Vitro

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.5%-0.05%, 1 h) reduces the infectivity of a classical enveloped virus such as West Nile virus (WNV)^[3].
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.19-0.20 mM) makes the HeLa cells underwent irreversible permeabilization of the membrane and structural collapse^[4].
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.01%, 1 h) induces apoptotic and necrotic death in prostate and colon cancer cell lines (PC-3, SW-620 and HT-29 cells), characterized by the typical morphological features and internucleosomal DNA fragmentation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.

9002-93-1

Appearance

Liquid (Density: 1.06 g/cm³)

Color

Colorless to light yellow

SMILES

CC(C)(C)CC(C)(C)C1=CC=C(OCCO)C=C1.[n]

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.20%

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Fiche technique (271 KB) SDS (758 KB)

COA (243 KB) RP-HPLC (204 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Colavita F, et al.Evaluation of the inactivation effect of Triton X-100 on Ebola virus infectivity. J Clin Virol. 2017 Jan;86:27-30. [Content Brief]

[2]. Herman SM, et al. The hidden allergen: Triton X-100, a derivative of polyethylene glycol. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2941. [Content Brief]

[3]. Koley D, et al. Triton X-100 concentration effects on membrane permeability of a single HeLa cell by scanning electrochemical microscopy (SECM). Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16783-7. [Content Brief]

[4]. Ghosh R, et al. Unraveling diverse action of triton X-100 and methimazole on lysozyme fibrillation/aggregation: Physicochemical insights. Int J Biol Macromol. 2021 Jan 15;167:736-745. [Content Brief]

[5]. Borner MM, et al. The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis. FEBS Lett. 1994 Oct 17;353(2):129-32. [Content Brief]