Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant
Based on 28 publication(s) in Google Scholar
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 9002-93-1
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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BSA Protein
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(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114
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Polyethylene glycol mono(4-tert-octylphenyl) ether
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Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO)
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Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO)
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Streptavidin Magnetic Beads
Publications Citing Use of MedChemExpress (MCE) Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant
More- Bioact Mater. 2023 Apr 17:27:271-287. [Abstract]
- Autophagy. 2023 Jun;19(6):1745-1763. [Abstract]
- ACS Nano. 2024 Mar 26;18(12):8777-8797. [Abstract]
- Theranostics. 2025 Jan 20;15(6):2360-2374. [Abstract]
- Adv Sci (Weinh). 2024 Nov;11(44):e2401931. [Abstract]
- Cell Death Dis. 2025 Oct 27;16(1):763. [Abstract]
- Mol Ther. 2025 Dec 3;33(12):6146-6159. [Abstract]
- Addit Manuf. 2025 May 25.
- Int J Surg. 2024 Jul 1;110(7):4103-4115. [Abstract]
- Int J Biol Macromol. 2025 Dec 11;338(Pt 1):149653. [Abstract]
- Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]
- Br J Pharmacol. 2026 Apr 26. [Abstract]
- J Agric Food Chem. 2026 Feb 25. [Abstract]
- Int J Pharm. 2024 Mar 25:653:123929. [Abstract]
- Cancer Metab. 2025 Aug 14;13(1):37. [Abstract]
- Cell Signal. 2026 Oct:146:112666. [Abstract]
- ACS Chem Neurosci. 2025 Feb 5;16(3):374-383. [Abstract]
- Pathogens. 2026 Jun 3;15(6):602. [Abstract]
- Int J Med Sci. 2023 Sep 4;20(10):1339-1357. [Abstract]
- Immun Inflamm Dis. 2024 Aug;12(8):e1341. [Abstract]
- Mol Biol Rep. 2026 May 27;53(1):850. [Abstract]
- Kaohsiung J Med Sci. 2025 Sep;41(9):e70045. [Abstract]
- Hum Cell. 2023 Jan;36(1):434-445. [Abstract]
- J Chin Med Assoc. 2026 Feb 1;89(2):140-150. [Abstract]
- Chinese medicine and natural products. 2024; 04(04): e173-e181.
- bioRxiv. 2024 October 17.
- Research Square Preprint. 2024 Apr 23.
- Biomed Pharmacother. 2023 Sep:165:115227. [Abstract]
Biological Activity
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.5%-0.05%, 1 h) reduces the infectivity of a classical enveloped virus such as West Nile virus (WNV)[3].
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.19-0.20 mM) makes the HeLa cells underwent irreversible permeabilization of the membrane and structural collapse[4].
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant (0.01%, 1 h) induces apoptotic and necrotic death in prostate and colon cancer cell lines (PC-3, SW-620 and HT-29 cells), characterized by the typical morphological features and internucleosomal DNA fragmentation[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9002-93-1
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Appearance Liquid (Density: 1.06 g/cm3)
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Color Colorless to light yellow
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SMILES
CC(C)(C)CC(C)(C)C1=CC=C(OCCO)C=C1.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (28)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction. [Abstract]2023 Apr 17:27:271-287. PMID: 37122901 -
Autophagy
The Valsa mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. [Abstract]2023 Jun;19(6):1745-1763. PMID: 36449354 -
ACS Nano
Osteoinductive Dental Pulp Stem Cell-Derived Extracellular Vesicle-Loaded Multifunctional Hydrogel for Bone Regeneration. [Abstract]2024 Mar 26;18(12):8777-8797. PMID: 38488479 -
Theranostics
Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury. [Abstract]2025 Jan 20;15(6):2360-2374. PMID: 39990234 -
Adv Sci (Weinh)
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. [Abstract]2024 Nov;11(44):e2401931. PMID: 39373388 -
Cell Death Dis
Hypoxia-induced exosomal LUCAT1 promotes osimertinib resistance in lung adenocarcinoma by stabilizing c-MET. [Abstract]2025 Oct 27;16(1):763. PMID: 41145422 -
Mol Ther
Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m6A modification. [Abstract]2025 Dec 3;33(12):6146-6159. PMID: 40914805 -
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Int J Surg
Pulsatile Flow Increases METTL14-induced m6A modification and attenuates septic cardiomyopathy: an experimental study. [Abstract]2024 Jul 1;110(7):4103-4115. PMID: 38549224 -
Int J Biol Macromol
BAG6 promotes hepatocellular carcinoma growth via enhancing PLK1-mediated aerobic glycolysis. [Abstract]2025 Dec 11;338(Pt 1):149653. PMID: 41390024 -
Free Radic Biol Med
2025 Aug 13:240:183-196. PMID: 40816648 -
Br J Pharmacol
Curcumin controls lysosomal acidification and exocytosis to ameliorate lysosomal cholesterol accumulation in Niemann-Pick type C disease. [Abstract]2026 Apr 26. PMID: 42036241 -
J Agric Food Chem
Oxygen-Driven Thermal Degradation of Isorhamnetin in Boiling Water: Product Profiling, Energetics, and Antiobesity Mechanisms in Caenorhabditis elegans. [Abstract]2026 Feb 25. PMID: 41738067 -
Int J Pharm
Selenium nanoparticles/carboxymethyl chitosan/alginate antioxidant hydrogel for treating steroid-induced osteonecrosis of the femoral head. [Abstract]2024 Mar 25:653:123929. PMID: 38387817 -
Cancer Metab
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming. [Abstract]2025 Aug 14;13(1):37. PMID: 40814066 -
Cell Signal
Mechanical stress attenuates the metabolic reprogramming and M1 polarization of macrophages by upregulating integrin subunit alpha D. [Abstract]2026 Oct:146:112666. PMID: 42270026 -
ACS Chem Neurosci
2025 Feb 5;16(3):374-383. PMID: 39800970 -
Pathogens
Egg Yolk Antibodies Elicited by a Novel Multi-Epitope Recombinant Adenovirus Vaccine Against Genotype G2b PEDV Spike Protein Reduce Mortality and Viral Shedding in Passively Immunized Piglets. [Abstract]2026 Jun 3;15(6):602. PMID: 42347214 -
Int J Med Sci
Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. [Abstract]2023 Sep 4;20(10):1339-1357. PMID: 37786443 -
Immun Inflamm Dis
Mechanism of desuccinylation of G6PD mediated by SIRT7 to promote vitiligo disease progression. [Abstract]2024 Aug;12(8):e1341. PMID: 39092715 -
Mol Biol Rep
Ameliorative effects of bevacizumab against sepsis-induced acute kidney injury: investigation of inflammatory responses, pyroptosis-related signalling and angiogenesis in a murine model of polymicrobial sepsis. [Abstract]2026 May 27;53(1):850. PMID: 42201618 -
Kaohsiung J Med Sci
Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury. [Abstract]2025 Sep;41(9):e70045. PMID: 40372180 -
Hum Cell
Establishment and characterization of a new Chinese hepatocellular carcinoma cell line, Hep-X1. [Abstract]2023 Jan;36(1):434-445. PMID: 36152230 -
J Chin Med Assoc
Single-cell omics in investigating the effect of CAFs with KRAS overexpression on the malignant progression of anaplastic thyroid cancer. [Abstract]2026 Feb 1;89(2):140-150. PMID: 41486477 -
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Biomed Pharmacother
The antimicrobial peptide chensinin-1b alleviates the inflammatory response by targeting the TLR4/NF-κB signaling pathway and inhibits Pseudomonas aeruginosa infection and LPS-mediated sepsis. [Abstract]2023 Sep:165:115227. PMID: 37536032
Solvent & Solubility
DMSO : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (758 KB)
- English - EN (758 KB)
- Français - FR (758 KB)
- Deutsch - DE (758 KB)
- Norwegian - NO (758 KB)
- Español - ES (758 KB)
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- Italian - IT (758 KB)
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Handling Instructions (2659 KB)
References
[1]. Colavita F, et al.Evaluation of the inactivation effect of Triton X-100 on Ebola virus infectivity. J Clin Virol. 2017 Jan;86:27-30. [Content Brief]
[2]. Herman SM, et al. The hidden allergen: Triton X-100, a derivative of polyethylene glycol. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2941. [Content Brief]
[3]. Koley D, et al. Triton X-100 concentration effects on membrane permeability of a single HeLa cell by scanning electrochemical microscopy (SECM). Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16783-7. [Content Brief]
[4]. Ghosh R, et al. Unraveling diverse action of triton X-100 and methimazole on lysozyme fibrillation/aggregation: Physicochemical insights. Int J Biol Macromol. 2021 Jan 15;167:736-745. [Content Brief]
[5]. Borner MM, et al. The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis. FEBS Lett. 1994 Oct 17;353(2):129-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant Related Classifications
HY-Y1883 Related Classifications
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