BOC-(1R,3S)-3-aminocyclopentane carboxylic acid
Based on 1 Customer Validation
BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ((1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a conformationally constrained peptide building block and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. When incorporated into macrocyclic peptides, BOC-(1R,3S)-3-aminocyclopentane carboxylic acid not only helps generate high-affinity Mpro inhibitors by preorganizing the secondary structure of peptides, but also exerts sequence-dependent functional inhibition on the hydrolytic activity of Mpro. BOC-(1R,3S)-3-aminocyclopentane carboxylic is widely used in COVID-19-related research.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 161660-94-2
- Formula: C11H19NO4
- Molecular Weight:229.28
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Chemical Information
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CAS No. 161660-94-2
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Appearance Solid
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Molecular Weight 229.28
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Formula C11H19NO4
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Color White to off-white
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SMILES
OC([C@@H]1CC[C@H](NC(OC(C)(C)C)=O)C1)=O
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Synonyms
(1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (436.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3615 mL | 21.8074 mL | 43.6148 mL | 109.0370 mL |
| 5 mM | 0.8723 mL | 4.3615 mL | 8.7230 mL | 21.8074 mL | |
| 10 mM | 0.4361 mL | 2.1807 mL | 4.3615 mL | 10.9037 mL | |
| 15 mM | 0.2908 mL | 1.4538 mL | 2.9077 mL | 7.2691 mL | |
| 20 mM | 0.2181 mL | 1.0904 mL | 2.1807 mL | 5.4518 mL | |
| 25 mM | 0.1745 mL | 0.8723 mL | 1.7446 mL | 4.3615 mL | |
| 30 mM | 0.1454 mL | 0.7269 mL | 1.4538 mL | 3.6346 mL | |
| 40 mM | 0.1090 mL | 0.5452 mL | 1.0904 mL | 2.7259 mL | |
| 50 mM | 0.0872 mL | 0.4361 mL | 0.8723 mL | 2.1807 mL | |
| 60 mM | 0.0727 mL | 0.3635 mL | 0.7269 mL | 1.8173 mL | |
| 80 mM | 0.0545 mL | 0.2726 mL | 0.5452 mL | 1.3630 mL | |
| 100 mM | 0.0436 mL | 0.2181 mL | 0.4361 mL | 1.0904 mL |
BOC-(1R,3S)-3-aminocyclopentane carboxylic acid Related Classifications
HY-W004812 Related Classifications
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Keywords
- BOC-(1R,3S)-3-aminocyclopentane carboxylic acid
- 161660-94-2
- (1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid
- Drug Intermediate
- SARS-CoV
- macrocyclic peptide libraries
- coronavirus disease 2019
- peptide secondary structures
- human serum
- bacterial autoinducer synthase CepI
- macrocyclic peptides
- SARS-CoV-2 main protease
- Mpro
- covid-19
- Inhibitor
- inhibitor
- inhibit