4-Fluorophenyl isothiocyanate
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4-Fluorophenyl isothiocyanate is an aryl isothiocyanate reagent and synthetic building block. 4-Fluorophenyl isothiocyanate is used to prepare quinazolinone derivatives, (S)-naproxen-derived 1,2,4-triazoles, isoniazid-derived thiosemicarbazones, isatin-β-thiosemicarbazones, thioureas, thiazolidinones, thiazolines, triazoles, and thiadiazoles. 4-Fluorophenyl isothiocyanate reacts with hydrazine to form a dimer of two thiocyanate groups linked by hydrazine, and the formation of this dimer can be avoided by reacting tert-butyl carbazate with the isothiocyanate.
For research use only. We do not sell to patients.
- CAS No.: 1544-68-9
- Formula: C7H4FNS
- Molecular Weight:153.17
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
286.9 μM
Compound: 7q
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
|
[PMID: 31784198] |
Chemical Information
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CAS No. 1544-68-9
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Appearance Solid
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Molecular Weight 153.17
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Formula C7H4FNS
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SMILES
FC1=CC=C(N=C=S)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)