tert-Butyl 2,2,2-trichloroacetimidate
Based on 1 Customer Validation
tert-Butyl 2,2,2-trichloroacetimidate is a tert-butylation reagent. tert-Butyl 2,2,2-trichloroacetimidate achieves mild, nonreversible tert-butylation of alcohols and phenols. tert-Butyl 2,2,2-trichloroacetimidate is used in the synthesis of antimicrobial agents.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 98946-18-0
- Formula: C6H10Cl3NO
- Molecular Weight:218.51
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 98946-18-0
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Appearance <21°C Solid,>21°C Liquid
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Molecular Weight 218.51
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Formula C6H10Cl3NO
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Color Light yellow to light brown
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SMILES
N=C(OC(C)(C)C)C(Cl)(Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (457.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (607 KB)
- English - EN (607 KB)
- Français - FR (607 KB)
- Deutsch - DE (607 KB)
- Norwegian - NO (607 KB)
- Español - ES (607 KB)
- Swedish - SV (607 KB)
- Italian - IT (607 KB)
- Korean - KR (607 KB)
- Portuguese - PT (607 KB)
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Handling Instructions (2659 KB)
References
[1]. Fandrick KR, et al. A Noncoordinating Acid-Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols. J Org Chem. 2021 Mar 19;86(6):4877-4882. [Content Brief]
[2]. Evans LE, et al. Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug. J Med Chem. 2019 May 9;62(9):4411-4425. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5764 mL | 22.8822 mL | 45.7645 mL | 114.4112 mL |
| 5 mM | 0.9153 mL | 4.5764 mL | 9.1529 mL | 22.8822 mL | |
| 10 mM | 0.4576 mL | 2.2882 mL | 4.5764 mL | 11.4411 mL | |
| 15 mM | 0.3051 mL | 1.5255 mL | 3.0510 mL | 7.6274 mL | |
| 20 mM | 0.2288 mL | 1.1441 mL | 2.2882 mL | 5.7206 mL | |
| 25 mM | 0.1831 mL | 0.9153 mL | 1.8306 mL | 4.5764 mL | |
| 30 mM | 0.1525 mL | 0.7627 mL | 1.5255 mL | 3.8137 mL | |
| 40 mM | 0.1144 mL | 0.5721 mL | 1.1441 mL | 2.8603 mL | |
| 50 mM | 0.0915 mL | 0.4576 mL | 0.9153 mL | 2.2882 mL | |
| 60 mM | 0.0763 mL | 0.3814 mL | 0.7627 mL | 1.9069 mL | |
| 80 mM | 0.0572 mL | 0.2860 mL | 0.5721 mL | 1.4301 mL | |
| 100 mM | 0.0458 mL | 0.2288 mL | 0.4576 mL | 1.1441 mL |
tert-Butyl 2,2,2-trichloroacetimidate Related Classifications
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