tert-Butyl carbazate

Cat. No.: HY-Y0373 Purity: 98.93%: Data Sheet
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tert-Butyl carbazate serves as a starting material for the preparation of heterocyclic and hydrazine derivatives. tert-Butyl carbazate undergoes coupling with aryl, heteroaryl, and alkenyl boronic acids to synthesize doubly protected monosubstituted hydrazines. Derivatives of tert-Butyl carbazate exhibit varying degrees of inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, and various fungi.

For research use only. We do not sell to patients.

tert-Butyl carbazate Chemical Structure

CAS No. : 870-46-2

Size	Stock	Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
250 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
1000 g	In-stock	Estimated Time of Arrival: December 31
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Description

In Vitro

tert-Butyl carbazate reacts with various boronic acid substrates at room temperature in organic solvent under copper(I) chloride catalysis to form diprotected monosubstituted hydrazine derivatives in in vitro synthetic experiments^[1].
tert-Butyl carbazate (compound 1) derived compound exhibit antimicrobial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis and Micrococcus luteus, Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Agrobacterium sp. and Erwinia sp., as well as fungi including Aspergillus flavus and Candida albicans, as demonstrated by the in vitro disk diffusion assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

132.16

Formula

C₅H₁₂N₂O₂

CAS No.

870-46-2

Appearance

<39°C Solid,>42°C Liquid

Color

White to yellow

SMILES

NNC(OC(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1513.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5666 mL	37.8329 mL	75.6659 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 99.93%

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Data Sheet (270 KB) SDS (604 KB)

COA (245 KB) HNMR (85 KB) GC (183 KB)

Handling Instructions (2659 KB)

References

[1]. Kabalka GW, et al. Synthesis of diprotected monosubstituted hydrazine derivatives from tert-butyl carbazates and boronic acids. Org Lett. 2003;5(22):4129-4131.

[2]. Şahin G, et al. Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives. Il Farmaco. 2002 Jul;57(7):539-542.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.5666 mL	37.8329 mL	75.6659 mL	189.1646 mL
	5 mM	1.5133 mL	7.5666 mL	15.1332 mL	37.8329 mL
	10 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	15 mM	0.5044 mL	2.5222 mL	5.0444 mL	12.6110 mL
	20 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	25 mM	0.3027 mL	1.5133 mL	3.0266 mL	7.5666 mL
	30 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	40 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7291 mL
	50 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	60 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	80 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	100 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8916 mL