1,3-Propanediol
Based on 1 Customer Validation
1,3-Propanediol is a versatile plant-derived humectant and solvent. 1,3-Propanediol can be produced by Klebsiella pneumoniae via glycerol fermentation, with the highest yield under anaerobic conditions. 1,3-Propanediol serves as a solvent and stabilizer in film preparation processes.
For research use only. We do not sell to patients.
- Purity: 98.82%
- CAS No.: 504-63-2
- Formula: C3H8O2
- Molecular Weight:76.09
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crl:CD(SD)BR (male and female, ~6 weeks old, initial body weights 160-201 g for males, 138-158 g for females)[1]
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Dosage:100 mg/kg/day; 300 mg/kg/day; 1000 mg/kg/day
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Administration:p.o.; daily; 90 days
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Result:Allowed all animals to survive to scheduled necropsy with no treatment-related clinical signs observed.
Left mean body weights, body weight gains, and food consumption unaffected at all dose levels.
Caused no treatment-related changes in hematology, serum chemistry, or coagulation parameters; any statistically significant differences were attributed to high control values or lacked a dose-response relationship.
Identified no treatment-related gross or microscopic tissue lesions, and kept organ weights comparable to controls.
Left spermatogenic endpoints (testicular and epididymal sperm numbers, sperm production rate, sperm motility, and sperm morphology) unaffected in all treated male rats.
Chemical Information
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CAS No. 504-63-2
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Appearance Liquid (Density: 1.053 g/cm3)
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Molecular Weight 76.09
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Formula C3H8O2
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Color Colorless to light yellow
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SMILES
OCCCO
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (1314.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 13.1423 mL | 65.7117 mL | 131.4233 mL | 328.5583 mL |
| 5 mM | 2.6285 mL | 13.1423 mL | 26.2847 mL | 65.7117 mL | |
| 10 mM | 1.3142 mL | 6.5712 mL | 13.1423 mL | 32.8558 mL | |
| 15 mM | 0.8762 mL | 4.3808 mL | 8.7616 mL | 21.9039 mL | |
| 20 mM | 0.6571 mL | 3.2856 mL | 6.5712 mL | 16.4279 mL | |
| 25 mM | 0.5257 mL | 2.6285 mL | 5.2569 mL | 13.1423 mL | |
| 30 mM | 0.4381 mL | 2.1904 mL | 4.3808 mL | 10.9519 mL | |
| 40 mM | 0.3286 mL | 1.6428 mL | 3.2856 mL | 8.2140 mL | |
| 50 mM | 0.2628 mL | 1.3142 mL | 2.6285 mL | 6.5712 mL | |
| 60 mM | 0.2190 mL | 1.0952 mL | 2.1904 mL | 5.4760 mL | |
| 80 mM | 0.1643 mL | 0.8214 mL | 1.6428 mL | 4.1070 mL | |
| 100 mM | 0.1314 mL | 0.6571 mL | 1.3142 mL | 3.2856 mL |
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