1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Lipoxygenase
    COX
  3. 2,5-Di-tert-butylhydroquinone

2,5-Di-tert-butylhydroquinone 

Cat. No.: HY-W012399
Handling Instructions

2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

For research use only. We do not sell to patients.

2,5-Di-tert-butylhydroquinone Chemical Structure

2,5-Di-tert-butylhydroquinone Chemical Structure

CAS No. : 88-58-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].

IC50 & Target[1]

5-LO

1.8 μM (IC50)

COX-2

14.1 μM (IC50)

In Vitro

DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro[1].

Molecular Weight

222.32

Formula

C₁₄H₂₂O₂

CAS No.

88-58-4

SMILES

OC1=CC(C(C)(C)C)=C(O)C=C1C(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (449.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4980 mL 22.4901 mL 44.9802 mL
5 mM 0.8996 mL 4.4980 mL 8.9960 mL
10 mM 0.4498 mL 2.2490 mL 4.4980 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

2,5-Di-tert-butylhydroquinoneLipoxygenaseCOXLOXCyclooxygenaseInhibitorinhibitorinhibit

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Product Name:
2,5-Di-tert-butylhydroquinone
Cat. No.:
HY-W012399
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