1. Cytoskeleton
  2. Dynamin

Dynasore 

Cat. No.: HY-15304 Purity: 99.61%
Handling Instructions

Dynasore is an inhibitor of the GTPase activity of dynamin with an IC50 of 15 μM.

For research use only. We do not sell to patients.

Dynasore Chemical Structure

Dynasore Chemical Structure

CAS No. : 304448-55-3

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10 mM * 1 mL in DMSO USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 82 In-stock
Estimated Time of Arrival: December 31
50 mg USD 374 In-stock
Estimated Time of Arrival: December 31
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Description

Dynasore is an inhibitor of the GTPase activity of dynamin with an IC50 of 15 μM.

IC50 & Target

IC50: 15 μM (GTPase activity of dynamin1 and 2)[1]

In Vitro

Dynasore interferes with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition. Two types of coated pit intermediates accumulate during dynasore treatment, g-shaped, half formed pits and O-shaped, fully formed pits, captured while pinching off[1]. Dynasore inhibits HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Dynasore reduces the number of viral capsids reaching the nuclear pore if added at the time of viral entry and that, when added as late as 8 h postentry, dynasore blocks the transport of newly synthesized viral proteins from the nucleus to the cytosol[2]. Dynasore prevents ischemia/reperfusion induced elevation of left ventricular end diastolic pressure. Dynasore also decreases cardiac troponin I efflux during reperfusion and reduces infarct size. In cultured adult mouse cardiomyocytes subjected to oxidative stress, dynasore increases cardiomyocyte survival and viability[3].

In Vivo

Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore significantly enhances motor function which may be by inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI[4].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1026 mL 15.5130 mL 31.0260 mL
5 mM 0.6205 mL 3.1026 mL 6.2052 mL
10 mM 0.3103 mL 1.5513 mL 3.1026 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[3]

Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 µM H2O2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to H2O2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[4]

Rats: In the dynasore groups, the rats are given dynasore immediately at a dose of 1, 10, or 30 mg/kg through intraperitoneal injection after SCI, while the rats in the sham and SCI groups receive DMSO (same volume as dynasore groups) through intraperitoneal injection[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

322.31

Formula

C₁₈H₁₄N₂O₄

CAS No.

304448-55-3

SMILES

O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC=C(O)C(O)=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.61%

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Product Name:
Dynasore
Cat. No.:
HY-15304
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Dynasore

Cat. No.: HY-15304