1. Cytoskeleton
  2. Dynamin
    Virus Protease
  3. Dynasore


Cat. No.: HY-15304 Purity: 98.70%
Handling Instructions

Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.

For research use only. We do not sell to patients.

Dynasore Chemical Structure

Dynasore Chemical Structure

CAS No. : 304448-55-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 82 In-stock
Estimated Time of Arrival: December 31
50 mg USD 374 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Dynasore purchased from MCE. Usage Cited in: J Am Chem Soc. 2018 Dec 12;140(49):17234-17240.

    HEK 293 cells are treated with different concentrations of Dynasore for indicated time. Then, the treated cells are collected and Western blot analysis is performed with indicated antibodies to detect LC3-I and LC3-II. GAPDH serves as the loading control.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review


    Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.

    IC50 & Target

    IC50: 15 μM (GTPase activity of dynamin1 and 2)[1]

    In Vitro

    Dynasore interferes with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition. Two types of coated pit intermediates accumulate during dynasore treatment, g-shaped, half formed pits and O-shaped, fully formed pits, captured while pinching off[1]. Dynasore inhibits HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Dynasore reduces the number of viral capsids reaching the nuclear pore if added at the time of viral entry and that, when added as late as 8 h postentry, dynasore blocks the transport of newly synthesized viral proteins from the nucleus to the cytosol[2]. Dynasore prevents ischemia/reperfusion induced elevation of left ventricular end diastolic pressure. Dynasore also decreases cardiac troponin I efflux during reperfusion and reduces infarct size. In cultured adult mouse cardiomyocytes subjected to oxidative stress, dynasore increases cardiomyocyte survival and viability[3].

    In Vivo

    Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore significantly enhances motor function which may be by inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI[4].

    Molecular Weight




    CAS No.





    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (155.13 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1026 mL 15.5130 mL 31.0260 mL
    5 mM 0.6205 mL 3.1026 mL 6.2052 mL
    10 mM 0.3103 mL 1.5513 mL 3.1026 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    Cell Assay

    Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 µM H2O2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to H2O2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration

    Rats: In the dynasore groups, the rats are given dynasore immediately at a dose of 1, 10, or 30 mg/kg through intraperitoneal injection after SCI, while the rats in the sham and SCI groups receive DMSO (same volume as dynasore groups) through intraperitoneal injection[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.


    Purity: 98.70%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2


    DynasoreDynaminAutophagyVirus ProteaseInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name



    Applicant Name *


    Email address *

    Phone number *


    Organization name *

    Department *


    Requested quantity *

    Country or Region *



    Bulk Inquiry

    Inquiry Information

    Product Name:
    Cat. No.:
    MCE Japan Authorized Agent: