Atorvastatin acetonide tert-butyl ester
Based on 1 Customer Validation
Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 125971-95-1
- Formula: C40H47FN2O5
- Molecular Weight:654.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 125971-95-1
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Appearance Solid
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Molecular Weight 654.81
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Formula C40H47FN2O5
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Color White to off-white
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SMILES
O=C(OC(C)(C)C)C[C@@H]1OC(C)(C)O[C@H](CCN2C(C3=CC=C(F)C=C3)=C(C4=CC=CC=C4)C(C(NC5=CC=CC=C5)=O)=C2C(C)C)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (190.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5272 mL | 7.6358 mL | 15.2716 mL | 38.1790 mL |
| 5 mM | 0.3054 mL | 1.5272 mL | 3.0543 mL | 7.6358 mL | |
| 10 mM | 0.1527 mL | 0.7636 mL | 1.5272 mL | 3.8179 mL | |
| 15 mM | 0.1018 mL | 0.5091 mL | 1.0181 mL | 2.5453 mL | |
| 20 mM | 0.0764 mL | 0.3818 mL | 0.7636 mL | 1.9090 mL | |
| 25 mM | 0.0611 mL | 0.3054 mL | 0.6109 mL | 1.5272 mL | |
| 30 mM | 0.0509 mL | 0.2545 mL | 0.5091 mL | 1.2726 mL | |
| 40 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9545 mL | |
| 50 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7636 mL | |
| 60 mM | 0.0255 mL | 0.1273 mL | 0.2545 mL | 0.6363 mL | |
| 80 mM | 0.0191 mL | 0.0954 mL | 0.1909 mL | 0.4772 mL | |
| 100 mM | 0.0153 mL | 0.0764 mL | 0.1527 mL | 0.3818 mL |
Atorvastatin acetonide tert-butyl ester Related Classifications
HY-135380 Related Classifications
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