tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate

Cat. No.: HY-W054424 Pureté: 99.96%: Fiche technique
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tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl) carbamate is a pharmaceutical intermediate used in the synthesis of various active compounds, such as for the preparation of tetrazole-based eIF2B activators.

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tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate Chemical Structure

CAS No. : 1638767-25-5

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
50 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtenir un devis

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Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

In Vitro

The core moiety of tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl) carbamate is bicyclo[1.1.1]pentane (BCP). Bicyclo[1.1.1]pentane (BCP) is a highly strained small bridged ring with abundant sp³-hybridized carbons.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

198.27

Formule

C₁₀H₁₈N₂O₂

CAS No.

1638767-25-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC12CC(N)(C2)C1)OC(C)(C)C

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (504.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0436 mL	25.2181 mL	50.4363 mL
5 mM	1.0087 mL	5.0436 mL	10.0873 mL
10 mM	0.5044 mL	2.5218 mL	5.0436 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.96%

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Fiche technique (270 KB) SDS (393 KB)

COA (246 KB) HNMR (424 KB) RP-HPLC (245 KB) MS (69 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Craig RA 2nd, et al. Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases. J Med Chem. 2024;67(7):5758-5782. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.0436 mL	25.2181 mL	50.4363 mL	126.0907 mL
	5 mM	1.0087 mL	5.0436 mL	10.0873 mL	25.2181 mL
	10 mM	0.5044 mL	2.5218 mL	5.0436 mL	12.6091 mL
	15 mM	0.3362 mL	1.6812 mL	3.3624 mL	8.4060 mL
	20 mM	0.2522 mL	1.2609 mL	2.5218 mL	6.3045 mL
	25 mM	0.2017 mL	1.0087 mL	2.0175 mL	5.0436 mL
	30 mM	0.1681 mL	0.8406 mL	1.6812 mL	4.2030 mL
	40 mM	0.1261 mL	0.6305 mL	1.2609 mL	3.1523 mL
	50 mM	0.1009 mL	0.5044 mL	1.0087 mL	2.5218 mL
	60 mM	0.0841 mL	0.4203 mL	0.8406 mL	2.1015 mL
	80 mM	0.0630 mL	0.3152 mL	0.6305 mL	1.5761 mL
	100 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2609 mL