1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 

Cat. No.: HY-21577
Handling Instructions

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure

CAS No. : 175724-30-8

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Description

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

505.64

Formula

C₂₅H₄₇NO₉

CAS No.

175724-30-8

SMILES

O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)(N)COCCC(OC(C)(C)C)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamineADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACcleavableInhibitorinhibitorinhibit

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Product name:
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
Cat. No.:
HY-21577
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