Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
Based on 1 Customer Validation
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 99.87%
- CAS No.: 175724-30-8
- Formula: C25H47NO9
- Molecular Weight:505.64
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
![Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure](https://file.medchemexpress.com/product_pic/hy-21577.gif "Click to View Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PEGs |
Cleavable Linker |
Alkyl/ether |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 175724-30-8
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Appearance Liquid (Density: 1.065±0.06 g/cm3)
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Molecular Weight 505.64
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Formula C25H47NO9
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Color Colorless to light yellow
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SMILES
O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)(N)COCCC(OC(C)(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 175 mg/mL (346.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9777 mL | 9.8885 mL | 19.7769 mL | 49.4423 mL |
| 5 mM | 0.3955 mL | 1.9777 mL | 3.9554 mL | 9.8885 mL | |
| 10 mM | 0.1978 mL | 0.9888 mL | 1.9777 mL | 4.9442 mL | |
| 15 mM | 0.1318 mL | 0.6592 mL | 1.3185 mL | 3.2962 mL | |
| 20 mM | 0.0989 mL | 0.4944 mL | 0.9888 mL | 2.4721 mL | |
| 25 mM | 0.0791 mL | 0.3955 mL | 0.7911 mL | 1.9777 mL | |
| 30 mM | 0.0659 mL | 0.3296 mL | 0.6592 mL | 1.6481 mL | |
| 40 mM | 0.0494 mL | 0.2472 mL | 0.4944 mL | 1.2361 mL | |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3955 mL | 0.9888 mL | |
| 60 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8240 mL | |
| 80 mM | 0.0247 mL | 0.1236 mL | 0.2472 mL | 0.6180 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1978 mL | 0.4944 mL |
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Related Classifications
HY-21577 Related Classifications
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