tert-Butyl (10-aminodecyl)carbamate
Based on 1 Customer Validation
tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine.
For research use only. We do not sell to patients.
- Purity : 97.0%
- CAS No.: 216961-61-4
- Formula: C15H32N2O2
- Molecular Weight:272.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
tert-Butyl (10-aminodecane) carbamate undergoes amide condensation to yield a Boc-protected intermediate, which is converted into compound 29 (MS479N1, a negative control PROTAC) via a series of reactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 216961-61-4
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Appearance Solid-Liquid Mixture
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Molecular Weight 272.43
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Formula C15H32N2O2
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Color Colorless to light yellow
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SMILES
O=C(OC(C)(C)C)NCCCCCCCCCCN
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Synonyms
1-Boc-1,10-diaminodecane
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (263 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Deng Z, et al. Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation. J Med Chem. 2025;68(8):8634-8647. [Content Brief]
[2]. Ying S, et al. Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer. J Med Chem. 2024;67(19):17053-17069. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
tert-Butyl (10-aminodecyl)carbamate Related Classifications
HY-W047688 Related Classifications
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