216961-61-4
Chemical Structure
tert-Butyl (10-aminodecyl)carbamate
Synonym(s): 1-Boc-1,10-diaminodecane
- CAS No.: 216961-61-4
- Formula:C15H32N2O2
- Molecular Weight:272.43
IUPAC Name: tert-butyl (10-aminodecyl)carbamate
InChIKey: RSAPJHYIFKJREV-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)NCCCCCCCCCCN
Biological Activity: tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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tert-Butyl (10-aminodecyl)carbamate | 97.0% | tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine. | ||||||||||||||||||||
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- [1]. Deng Z, et al. Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation. J Med Chem. 2025;68(8):8634-8647. [Content Brief]
- [2]. Ying S, et al. Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer. J Med Chem. 2024;67(19):17053-17069. [Content Brief]
Keywords
