2. PROTAC
  3. PROTAC Linkers
  4. Boc-NH-C12-NH2

Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Boc-NH-C12-NH2

Boc-NH-C12-NH2 Chemical Structure

CAS No. : 109792-60-1

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Boc-NH-C12-NH2 Related Antibodies

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Description

Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-NH-C12-NH2 Related Antibodies
Molecular Weight

300.48

Formula

C17H36N2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NCCCCCCCCCCCCNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (116.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3280 mL 16.6400 mL 33.2801 mL
5 mM 0.6656 mL 3.3280 mL 6.6560 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

SDS (393 KB)

COA (239 KB) HNMR (250 KB) LCMS (315 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3280 mL 16.6400 mL 33.2801 mL 83.2002 mL
5 mM 0.6656 mL 3.3280 mL 6.6560 mL 16.6400 mL
10 mM 0.3328 mL 1.6640 mL 3.3280 mL 8.3200 mL
15 mM 0.2219 mL 1.1093 mL 2.2187 mL 5.5467 mL
20 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
25 mM 0.1331 mL 0.6656 mL 1.3312 mL 3.3280 mL
30 mM 0.1109 mL 0.5547 mL 1.1093 mL 2.7733 mL
40 mM 0.0832 mL 0.4160 mL 0.8320 mL 2.0800 mL
50 mM 0.0666 mL 0.3328 mL 0.6656 mL 1.6640 mL
60 mM 0.0555 mL 0.2773 mL 0.5547 mL 1.3867 mL
80 mM 0.0416 mL 0.2080 mL 0.4160 mL 1.0400 mL
100 mM 0.0333 mL 0.1664 mL 0.3328 mL 0.8320 mL
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Boc-NH-C12-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-NH-C12-NH2109792-60-1PROTAC LinkersInhibitorinhibitorinhibit

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