2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid
Based on 1 Customer Validation
2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 96.83%
- CAS No.: 120289-22-7
- Formula: C8H14O5
- Molecular Weight:190.20
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
![2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w108133.gif "Click to View 2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E224 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 120289-22-7
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Appearance Solid
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Molecular Weight 190.20
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Formula C8H14O5
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Color White to off-white
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SMILES
O=C(O)COCC(=O)OC(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (525.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2576 mL | 26.2881 mL | 52.5762 mL | 131.4406 mL |
| 5 mM | 1.0515 mL | 5.2576 mL | 10.5152 mL | 26.2881 mL | |
| 10 mM | 0.5258 mL | 2.6288 mL | 5.2576 mL | 13.1441 mL | |
| 15 mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 8.7627 mL | |
| 20 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 6.5720 mL | |
| 25 mM | 0.2103 mL | 1.0515 mL | 2.1030 mL | 5.2576 mL | |
| 30 mM | 0.1753 mL | 0.8763 mL | 1.7525 mL | 4.3814 mL | |
| 40 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 3.2860 mL | |
| 50 mM | 0.1052 mL | 0.5258 mL | 1.0515 mL | 2.6288 mL | |
| 60 mM | 0.0876 mL | 0.4381 mL | 0.8763 mL | 2.1907 mL | |
| 80 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6430 mL | |
| 100 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.3144 mL |
2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid Related Classifications
HY-W108133 Related Classifications
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