tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

Cat. No.: HY-30605 Purity: 99.82%: Data Sheet
COA

SDS
Handling Instructions
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tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Chemical Structure

CAS No. : 336191-17-4

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Description

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E927 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

240.35

Formula

C₁₃H₂₄N₂O₂

CAS No.

336191-17-4

Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

O=C(OC(C)(C)C)N1CCC2(C1)CCNCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 70 mg/mL (291.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1606 mL	20.8030 mL	41.6060 mL
5 mM	0.8321 mL	4.1606 mL	8.3212 mL
10 mM	0.4161 mL	2.0803 mL	4.1606 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (242 KB) SDS (393 KB)

COA (247 KB) HNMR (113 KB) RP-HPLC (177 KB) MS (74 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1606 mL	20.8030 mL	41.6060 mL	104.0150 mL
	5 mM	0.8321 mL	4.1606 mL	8.3212 mL	20.8030 mL
	10 mM	0.4161 mL	2.0803 mL	4.1606 mL	10.4015 mL
	15 mM	0.2774 mL	1.3869 mL	2.7737 mL	6.9343 mL
	20 mM	0.2080 mL	1.0401 mL	2.0803 mL	5.2007 mL
	25 mM	0.1664 mL	0.8321 mL	1.6642 mL	4.1606 mL
	30 mM	0.1387 mL	0.6934 mL	1.3869 mL	3.4672 mL
	40 mM	0.1040 mL	0.5201 mL	1.0401 mL	2.6004 mL
	50 mM	0.0832 mL	0.4161 mL	0.8321 mL	2.0803 mL
	60 mM	0.0693 mL	0.3467 mL	0.6934 mL	1.7336 mL
	80 mM	0.0520 mL	0.2600 mL	0.5201 mL	1.3002 mL
	100 mM	0.0416 mL	0.2080 mL	0.4161 mL	1.0401 mL