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Cat. No.: HY-161931

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Demethyl-RSL3-boc

Demethyl-RSL3-boc is a key intermediate in the synthesis of PROTAC compounds, containing a tert-butyl group.

For research use only. We do not sell to patients.

CAS No.: 2375354-07-5
Formula: C₂₆H₂₇ClN₂O₅
Molecular Weight:482.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Demethyl-RSL3-boc Chemical Structure

CAS No.: 2375354-07-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Demethyl-RSL3-boc is a key intermediate in the synthesis of PROTAC compounds, containing a tert-butyl group^[1].

Chemical Information

CAS No. 2375354-07-5
Molecular Weight 482.96
Formula C₂₆H₂₇ClN₂O₅
SMILES

O=C(OC)[C@@H](C1)N(C(CCl)=O)[C@@H](C2=CC=C(C(OC(C)(C)C)=O)C=C2)C3=C1C4=CC=CC=C4N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ning Y, et al. Design, synthesis, and biological evaluation of RSL3-based GPX4 degraders with hydrophobic tags. Eur J Med Chem. 2024 Nov 5;277:116719. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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