3’-O-t-Bulyldimethylsilylthymidine
Based on 1 Customer Validation
3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 40733-27-5
- Formula: C16H28N2O5Si
- Molecular Weight:356.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
400 μM
Compound: TBS-T
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Cytotoxicity in C8166 cell lines
Cytotoxicity in C8166 cell lines
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10.1016/0960-894X(96)00443-X |
| C8166 | EC50 |
16 μM
Compound: TBS-T
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Anti-HIV activity against HIV-1 infected C8166 cell lines
Anti-HIV activity against HIV-1 infected C8166 cell lines
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10.1016/0960-894X(96)00443-X |
| JM1 | CC50 |
400 μM
Compound: TBS-T
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Concentration required to reduce cell viability of JM cells by 50%
Concentration required to reduce cell viability of JM cells by 50%
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10.1016/0960-894X(96)00443-X |
| JM1 | EC50 |
20 μM
Compound: TBS-T
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Anti-HIV activity against HIV-1 infected JM cell lines
Anti-HIV activity against HIV-1 infected JM cell lines
|
10.1016/0960-894X(96)00443-X |
Chemical Information
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CAS No. 40733-27-5
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Appearance Solid
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Molecular Weight 356.49
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Formula C16H28N2O5Si
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](N2C(NC(C(C)=C2)=O)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (280.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8051 mL | 14.0256 mL | 28.0513 mL | 70.1282 mL |
| 5 mM | 0.5610 mL | 2.8051 mL | 5.6103 mL | 14.0256 mL | |
| 10 mM | 0.2805 mL | 1.4026 mL | 2.8051 mL | 7.0128 mL | |
| 15 mM | 0.1870 mL | 0.9350 mL | 1.8701 mL | 4.6752 mL | |
| 20 mM | 0.1403 mL | 0.7013 mL | 1.4026 mL | 3.5064 mL | |
| 25 mM | 0.1122 mL | 0.5610 mL | 1.1221 mL | 2.8051 mL | |
| 30 mM | 0.0935 mL | 0.4675 mL | 0.9350 mL | 2.3376 mL | |
| 40 mM | 0.0701 mL | 0.3506 mL | 0.7013 mL | 1.7532 mL | |
| 50 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4026 mL | |
| 60 mM | 0.0468 mL | 0.2338 mL | 0.4675 mL | 1.1688 mL | |
| 80 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8766 mL | |
| 100 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.7013 mL |
3’-O-t-Bulyldimethylsilylthymidine Related Classifications
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