tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate
Based on 1 Customer Validation
tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 98.54%
- CAS No.: 1363381-95-6
- Formula: C12H21NO3
- Molecular Weight:227.30
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
![tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w050186.gif "Click to View tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E1042 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1363381-95-6
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Appearance Solid-Liquid Mixture
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Molecular Weight 227.30
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Formula C12H21NO3
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Color Colorless to off-white
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SMILES
O=C(OC(C)(C)C)N1CC2(C1)CCC(O)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (439.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (242 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3995 mL | 21.9974 mL | 43.9947 mL | 109.9868 mL |
| 5 mM | 0.8799 mL | 4.3995 mL | 8.7989 mL | 21.9974 mL | |
| 10 mM | 0.4399 mL | 2.1997 mL | 4.3995 mL | 10.9987 mL | |
| 15 mM | 0.2933 mL | 1.4665 mL | 2.9330 mL | 7.3325 mL | |
| 20 mM | 0.2200 mL | 1.0999 mL | 2.1997 mL | 5.4993 mL | |
| 25 mM | 0.1760 mL | 0.8799 mL | 1.7598 mL | 4.3995 mL | |
| 30 mM | 0.1466 mL | 0.7332 mL | 1.4665 mL | 3.6662 mL | |
| 40 mM | 0.1100 mL | 0.5499 mL | 1.0999 mL | 2.7497 mL | |
| 50 mM | 0.0880 mL | 0.4399 mL | 0.8799 mL | 2.1997 mL | |
| 60 mM | 0.0733 mL | 0.3666 mL | 0.7332 mL | 1.8331 mL | |
| 80 mM | 0.0550 mL | 0.2750 mL | 0.5499 mL | 1.3748 mL | |
| 100 mM | 0.0440 mL | 0.2200 mL | 0.4399 mL | 1.0999 mL |
tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate Related Classifications
HY-W050186 Related Classifications
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