2. Gene
  3. PPP2R5A - protein phosphatase 2 regulatory subunit B'alpha Gene

PPP2R5A - protein phosphatase 2 regulatory subunit B'alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B56A; PR61A; B56alpha

Gene ID: 5525 | Gene type: protein coding

About PPP2R5A

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,285,410-212,361,853 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 41.9), lung (RPKM 33.2) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PPP2R5A Products(2)

mRNA Protein Name
NM_001199756.2 NP_001186685.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 2
NM_006243.4 NP_006234.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1

PPP2R5A Protein Structure

B56

B56: Protein phosphatase 2A regulatory B subunit (B56 family) (55 - 461)

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  • 486 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

PR61alpha

Related Diseases

Diseases Alias
Progressive Familial Heart Block, Type Ii

PFHB2

Pfhbii

Progressive Familial Heart Block Type Ii

Progressive Familial Heart Block Type 2

Heart Block Progressive Familial Type 2
Cardiomyopathy, Dilated, 1d

Dilated Cardiomyopathy 1d

CMD1D

Left Ventricular Noncompaction 6, Included

Lvnc6, Included

Left Ventricular Noncompaction 6

Cardiomyopathy, Dilated 1d
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11018 PPP2R5A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPP2R5A VGNC VGNC:76379
Canis familiaris PPP2R5A VGNC VGNC:44913
Mus musculus PPP2R5A MGD MGI:2388479
Felis catus PPP2R5A VGNC VGNC:69015
Bos taurus PPP2R5A VGNC VGNC:33260
Rattus norvegicus PPP2R5A RGD RGD:1308022