SGO2 - shugoshin 2 Gene

Also Known as SGOL2; TRIPIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151246

About SGO2

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,526,142-200,584,096 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 1 paralogue. Biased expression in testis (RPKM 14.8), lymph node (RPKM 3.1) and 10 other tissues.

Summary

Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Apr 2022]

SGO2 Products (3)

mRNA Protein Name
NM_001160033.1 NP_001153505.1 shugoshin 2 isoform 2
NM_001160046.1 NP_001153518.1 shugoshin 2 isoform 3
NM_152524.6 NP_689737.4 shugoshin 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16541025 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
17485487 GOA
part of mitotic cohesin complex IDA
IDA: Inferred from direct assay
18084284 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

shugoshin 2

  • shugoshin-like 2

SGO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SGO2 Q562F6 PPP1CA Homo sapiens P62136
Anti Bait CoIP
21666598
Intra
SGO2 Q562F6 PPP1CA Homo sapiens P62136
Anti Tag CoIP
21666598
Intra
SGO2 Q562F6 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
16541025
Intra
SGO2 Q562F6 PPP2CA Homo sapiens P67775
Anti Bait CoIP
16541025
Intra
SGO2 Q562F6 PPP2CA Homo sapiens P67775
Anti Tag CoIP
33961781
Intra
SGO2 Q562F6 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
21666598
Intra
SGO2 Q562F6 MAD2L1 Homo sapiens Q13257
Y2H
21666598
Intra
SGO2 Q562F6 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
21666598
Intra
SGO2 Q562F6 MAD2L1 Homo sapiens Q13257
ITC
21666598
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Perrault Syndrome

  • Gonadal Dysgenesis, Xx Type, With Deafness

  • Ovarian Dysgenesis With Sensorineural Deafness

  • Gonadal Dysgenesis, Xx Type

  • Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

  • Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

  • Xx Gonodal Dysgenesis-Deafness Syndrome

  • Xx Gonodal Dysgenesis-Hearing Loss Syndrome

  • Gonadal Dysgenesis Xx Type Deafness
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Chronic Atrial And Intestinal Dysrhythmia

  • CAID

  • Caid Syndrome

  • Cohesinopathy Affecting Heart And Gut Rhythm

  • Chronic Atrial Intestinal Dysrhythmia Syndrome

  • Chronic Atrial And Intestinal Dysrhythmia Syndrome

  • Chronic Atrial Dysrhythmia-Intestinal Motility Disorder

  • Dysrhythmia, Atrial And Intestinal, Chronic
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12808 SGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SGO2 VGNC VGNC:34546
Mus musculus SGO2 MGD MGI:1098767
Macaca mulatta SGO2 VGNC VGNC:104555
Rattus norvegicus SGO2 RGD RGD:1308450
Felis catus SGO2 VGNC VGNC:65082
Canis familiaris SGO2 VGNC VGNC:46101
Others SGO2 NCBI