PPP2R1A - protein phosphatase 2 scaffold subunit Aalpha Gene

Also Known as MRD36; PP2AA; PR65A; PP2AAALPHA; PP2A-Aalpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5518

About PPP2R1A

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:52,190,052-52,229,518 (from NCBI)

This gene has 22 transcripts (splice variants), 127 orthologues, 2 paralogues and is associated with 96 phenotypes. Ubiquitous expression in heart (RPKM 78.3), adrenal (RPKM 73.7) and 25 other tissues.

Summary

This gene encodes a constant regulatory subunit of protein Phosphatase 2. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R1A Products (2)

mRNA	Protein	Name
NM_001363656.2	NP_001350585.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 2
NM_014225.6	NP_055040.2	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein antigen binding	IPI IPI: Inferred from physical interaction	9847399	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8617797	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9847399	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromosome segregation	IDA IDA: Inferred from direct assay	16580887	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	33633399	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	16580887	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	15525651	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	15525651	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	15525651	GOA
located in nucleus	IDA IDA: Inferred from direct assay	30611118	GOA
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	17055435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R1A Protein Structure

HEAT_2

HEAT

HEAT_2

0
100
200
300
400
500
589 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	medium tumor antigen-associated 61 KDA protein

PPP2R1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R1A	P30153	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	GOLGA8F	Homo sapiens	Q08AF8	Validated Y2H	32296183
Intra	PPP2R1A	P30153	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	32296183
Intra	PPP2R1A	P30153	PPP4C	Homo sapiens	P60510	BioID	28330616
Intra	PPP2R1A	P30153	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP4C	Homo sapiens	P60510	Pull Down	28330616
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	TAP	18782753
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	BioID	28330616
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	Anti Tag CoIP	17540176
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	17632056
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Comig Non-Denat Gel	17529992
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	17245430
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	TAP	19293187
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	TAP	27173435
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	TAP	15761952
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	19915589
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	19156129
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	17540176
Intra	PPP2R1A	P30153	PPP2R2A	Homo sapiens	P63151	BioID	28330616
Intra	PPP2R1A	P30153	PPP2R2B	Homo sapiens	Q00005	Pull Down	17274953
Intra	PPP2R1A	P30153	PPP2R2B	Homo sapiens	Q00005	Anti Tag CoIP	17274953
Intra	PPP2R1A	P30153	PPP2R2B	Homo sapiens	Q00005	Anti Tag CoIP	21075311
Intra	PPP2R1A	P30153	PPP2R2B	Homo sapiens	Q00005	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	Validated Y2H	32296183
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	3D-EM-Single	33633399
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	Y2H Array	32296183
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	GMS	33633399
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	Anti Tag CoIP	19156129
Intra	PPP2R1A	P30153	STRN3	Homo sapiens	Q13033-2	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	PPP2R1A	P30153	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	PPP2R1A	P30153	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	FBXO43	Homo sapiens	Q4G163	Validated Y2H	32296183
Intra	PPP2R1A	P30153	FBXO43	Homo sapiens	Q4G163	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	FBXO43	Homo sapiens	Q4G163	Y2H Array	32296183
Intra	PPP2R1A	P30153	PTPA	Homo sapiens	Q15257-2	Y2H Array	32296183
Intra	PPP2R1A	P30153	PTPA	Homo sapiens	Q15257-2	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	PTPA	Homo sapiens	Q15257-2	Validated Y2H	32296183
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	19915589
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	TAP	27173435
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	17245430
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	BioID	28330616
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362	TAP	18782753
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362-1	Y2H	8617797
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362-1	Pull Down	8617797
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362-1	Anti Tag CoIP	19156129
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362-2	Comig Non-Denat Gel	17529992
Intra	PPP2R1A	P30153	PPP2R5C	Homo sapiens	Q13362-2	Pull Down	8617797
Cross	PPP2R1A	P30153	st_sv40	Simian virus 40	P03081	Pull Down	9857076
Cross	PPP2R1A	P30153	st_sv40	Simian virus 40	P03081	Comig Non-Denat Gel	17529992
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815-2	Y2H Array	32296183
Intra	PPP2R1A	P30153	STRN	Homo sapiens	O43815-2	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R5B	Homo sapiens	Q15173	Validated Y2H	32296183
Intra	PPP2R1A	P30153	CIP2A	Homo sapiens	Q8TCG1	Confocal	17632056
Intra	PPP2R1A	P30153	CIP2A	Homo sapiens	Q8TCG1	Anti Tag CoIP	17632056
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775-1	GMS	33633399
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775-1	Anti Tag CoIP	33633399
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775-1	3D-EM-Single	33633399
Intra	PPP2R1A	P30153	CSDC2	Homo sapiens	Q9Y534	Y2H Array	32296183
Intra	PPP2R1A	P30153	CSDC2	Homo sapiens	Q9Y534	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	CSDC2	Homo sapiens	Q9Y534	Validated Y2H	32296183
Intra	PPP2R1A	P30153	AKT1	Homo sapiens	P31749	Pull Down	16044149
Cross	PPP2R1A	P30153	Nxn	Mus musculus	P97346	Anti Tag CoIP	16764867
Cross	PPP2R1A	P30153	Nxn	Mus musculus	P97346	Pull Down	16764867
Intra	PPP2R1A	P30153	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	TP53	Homo sapiens	P04637	Pull Down	17245430
Intra	PPP2R1A	P30153	TP53	Homo sapiens	P04637	PLA	25241761
Intra	PPP2R1A	P30153	TP53	Homo sapiens	P04637	Anti Bait CoIP	17245430
Intra	PPP2R1A	P30153	CCNG1	Homo sapiens	P51959	Pull Down	28330616
Intra	PPP2R1A	P30153	CCNG1	Homo sapiens	P51959	Pull Down	17245430
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	BioID	28330616
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	TAP	19293187
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	TAP	18782753
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	TAP	27173435
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Validated Y2H	32296183
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Y2H	23555304
Intra	PPP2R1A	P30153	PPP2R5D	Homo sapiens	Q14738	Y2H Array	32296183
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	18782753
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	BioID	28330616
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	17245430
Intra	PPP2R1A	P30153	PPP2R5A	Homo sapiens	Q15172	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	GMS	17055435
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	Pull Down	17274953
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	17274953
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	Comig Non-Denat Gel	17529992
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	TAP	15761952
Intra	PPP2R1A	P30153	PPP2CA	Homo sapiens	P67775	X-Ray Diffraction	17055435
Intra	PPP2R1A	P30153	PPP5C	Homo sapiens	P53041	Pull Down	11504734
Intra	PPP2R1A	P30153	CARHSP1	Homo sapiens	Q9Y2V2	Validated Y2H	32296183
Intra	PPP2R1A	P30153	CARHSP1	Homo sapiens	Q9Y2V2	Y2H Array	32296183
Intra	PPP2R1A	P30153	CARHSP1	Homo sapiens	Q9Y2V2	Y2H Prey Pooling	32296183
Intra	PPP2R1A	P30153	RELA	Homo sapiens	Q04206	Pull Down	11591705
Intra	PPP2R1A	P30153	PLAAT3	Homo sapiens	P53816	Anti Tag CoIP	17374643
Intra	PPP2R1A	P30153	PLAAT3	Homo sapiens	P53816	Y2H	17374643
Cross	PPP2R1A	P30153	E7	Human papillomavirus	P03129	Pull Down	16044149
Cross	PPP2R1A	P30153	E7	Human papillomavirus	P03129	CoIP	16044149
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	19156129
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	BioID	28330616
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	Pull Down	28330616
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	33961781
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	TAP	27173435
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	26496610
Intra	PPP2R1A	P30153	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	18782753

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 36	MRD36 Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome Autosomal Dominant Non-Syndromic Intellectual Disability 36 Mental Retardation, Autosomal Dominant 36 Autosomal Dominant Intellectual Developmental Disorder 36 Autosomal Dominant Mental Retardation 36 Mental Retardation, Autosomal Dominant, Type 36
Ppp2r1a-Related Neurodevelopmental Disorder	Ppp2r1a-Related Neurodevelopmental Disorders
Motor Stereotypies	Motor Stereotypy
Brachydactyly
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Uterine Carcinosarcoma	Carcinosarcoma Of The Corpus Uteri Mixed Mullerian Sarcoma Of Uterus Malignant Mixed Müllerian Tumor Of The Corpus Uteri Malignant Mixed Müllerian Tumor Of Corpus Uteri Mixed Müllerian Cancer Of Corpus Uteri Malignant Mixed Mullerian Tumor Of The Corpus Uteri Mixed Mullerian Cancer Of Corpus Uteri Uterine Corpus Carcinosarcoma
Ovarian Serous Cystadenocarcinoma	Serous Cystadenoma Cystadenoma Serous Cystadenoma, Serous
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Uterine Corpus Endometrial Carcinoma
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Endometrial Serous Adenocarcinoma	Uterine Serous Carcinoma Uterine Corpus Serous Adenocarcinoma Uterine Papillary Serous Carcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Uterine Body Mixed Cancer	Malignant Mixed Tumor Of Corpus Uteri Malignant Mixed Tumor, Not Otherwise Specified
Rete Ovarii Adenocarcinoma	Adenocarcinoma Of Rete Ovarii
Endometrioid Ovary Carcinoma	Endometrioid Carcinoma Of Ovary Endometrioid Carcinoma Ovary Ovarian Endometrioid Carcinoma Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Tumor
Female Reproductive Endometrioid Cancer	Endometrioid Tumor Endometrioid Neoplasm Female Reproductive Endometrioid Neoplasm
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Mixed Cell Type Cancer	Malignant Mixed Neoplasm Malignant Mixed Tumor Mixed Neoplasm Mixed Tumor, Malignant Malignant Mixed Cancer Mixed Tumor Malignant Mixed Tumor, Not Otherwise Specified Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3 EEC3 Eec Syndrome 3 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Salpingitis Isthmica Nodosa
Ovarian Carcinosarcoma	Ovarian Malignant Mixed Mullerian Tumor Mmmt Of The Ovary Malignant Mixed Mullerian Tumor Of The Ovary Ovarian Malignant Mixed Epithelial Mesenchymal Tumor Ovarian Malignant Mesodermal Mixed Tumor Ovarian Mmmt Malignant Mixed Müllerian Tumor Of The Ovary Ovarian Malignant Mixed Müllerian Tumor Carcinosarcoma Of Ovary
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Endometriosis Of Ovary	Ovarian Endometriosis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11009	PPP2R1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18724	Ppp2r1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25211	Ppp2r1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP2R1A	VGNC	VGNC:69009
Canis familiaris	PPP2R1A	VGNC	VGNC:44905
Bos taurus	PPP2R1A	VGNC	VGNC:33253
Macaca mulatta	PPP2R1A	VGNC	VGNC:76374
Mus musculus	PPP2R1A	MGD	MGI:1926334
Rattus norvegicus	PPP2R1A	RGD	RGD:620907
Others	PPP2R1A	NCBI