CIP2A - cellular inhibitor of PP2A Gene

Also Known as p90; NOCIVA; KIAA1524

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57650

About CIP2A

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,549,864-108,589,438 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 2 paralogues. Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues.

Summary

Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CIP2A Products (1)

mRNA Protein Name
NM_020890.3 NP_065941.2 protein CIP2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17632056 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
28174209 GOA
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
17632056 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
35842428 GOA
involved in broken chromosome clustering IDA
IDA: Inferred from direct assay
37165191 GOA
involved in chromosome organization IDA
IDA: Inferred from direct assay
35121901 GOA
Cellular Component GO Annotation Evidence References Source
is active in chromosome IDA
IDA: Inferred from direct assay
35121901 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein CIP2A

  • cancerous inhibitor of PP2A

CIP2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CIP2A Q8TCG1 PPP2R1A Homo sapiens P30153
Anti Bait CoIP
17632056
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N4317 Ethoxysanguinarine Inducer 98.81% Unkown
HY-135699 TD52 95.0% Unkown
HY-135699A TD52 dihydrochloride 99.55% Unkown
HY-139296 PP2A Cancerous-IN-1 Inhibitor / Unkown
HY-RS02718 CIP2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18384 Cip2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24865 Cip2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CIP2A RGD RGD:1310335
Canis familiaris CIP2A VGNC VGNC:39277
Felis catus CIP2A VGNC VGNC:60906
Bos taurus CIP2A VGNC VGNC:27369
Macaca mulatta CIP2A VGNC VGNC:71371
Mus musculus CIP2A MGD MGI:2146335
Others CIP2A NCBI